{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:13:27Z","timestamp":1790921607919,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Given the Centers for Medicare and Medicaid Services' coverage of screening CT colonography (CTC) beginning in January 2025, we evaluated the cost\u2010effectiveness of CTC for colorectal cancer (CRC) screening by race (Black and White) and gender, considering real\u2010world screening adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A microsimulation model compared CRC screening strategies in average\u2010risk adults by race and gender, incorporating 2010\u20132019\u2009U.S. data on disease progression and real\u2010world screening adherence for colonoscopy and fecal immunochemical test (FIT). Five strategies were compared: (1) status quo (choice between colonoscopy and FIT); (2) CTC every 5\u2009years; (3) colonoscopy every 10\u2009years; (4) annual FIT; and (5) multitarget stool DNA test every 3\u2009years, plus no screening. Lifetime costs, quality\u2010adjusted life years gained (QALYG), and incremental cost\u2010effectiveness ratios were projected. A willingness\u2010to\u2010pay threshold of $100,000\/QALYG was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Under the status quo, Black adults showed higher CRC cases and greater utilization for FIT over colonoscopy than White adults. Compared to the status quo, the CTC strategy yielded more QALYG and fewer CRC cases among Black adults, but fewer QALYG and more CRC cases among White adults. Both status quo and CTC strategies outperformed other strategies across races. The CTC strategy was the dominant strategy for Black adults. For White adults, the status quo was cost\u2010effective with incremental cost\u2010effectiveness ratios of $34,998\u2013$73,428\/QALYG, while the CTC strategy was cost saving compared to no screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CTC could be cost\u2010effective for CRC screening in Black adults under real\u2010world screening adherence, supporting Medicare coverage to address specific population needs and structural barriers to screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71290","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:16:48Z","timestamp":1763018208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost\u2010Effectiveness of\n                    <scp>CT<\/scp>\n                    Colonography Under Real\u2010World Colorectal Cancer Screening Adherence for Black and White Populations"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-3983","authenticated-orcid":false,"given":"Szu\u2010Yu Zoe","family":"Kao","sequence":"first","affiliation":[{"name":"Siemens Medical Solutions USA Inc.  Malvern Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria X.","family":"Sanmartin","sequence":"additional","affiliation":[{"name":"Northwell  New York New York USA"},{"name":"Department of Radiology Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine, Montefiore Health System  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-2740","authenticated-orcid":false,"given":"Kevin J.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center and Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-2480","authenticated-orcid":false,"given":"Courtney A.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6523-8050","authenticated-orcid":false,"given":"Cecelia","family":"Brewington","sequence":"additional","affiliation":[{"name":"Department of Radiology Ochsner Health System  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Bruining","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-0787","authenticated-orcid":false,"given":"Eric W.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Harvey L. Neiman Health Policy Institute  Reston Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-1102","authenticated-orcid":false,"given":"Elizabeth Y.","family":"Rula","sequence":"additional","affiliation":[{"name":"Harvey L. 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