{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:30:55Z","timestamp":1786458655989,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702093"],"award-info":[{"award-number":["81702093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer remains one of the most prevalent cancers among men worldwide, particularly in the context of metastatic castration\u2010resistant prostate cancer (mCRPC), which poses significant treatment challenges. PARP inhibitors offer a promising therapeutic option for patients with homologous recombination repair (HRR) deficiencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study systematically analyzed 630 registered clinical trials related to prostate cancer and PARP inhibitors as of April 25, 2025. A total of 109 trials were included, focusing on key information such as year of initiation, trial phase, targeted populations, and study designs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings indicate a significant increase in clinical trials involving PARP inhibitors from 2012 to 2025. Multi\u2010national collaborative studies accounted for 39.4% of the trials, with the United States being the principal contributing country. The majority of trials are concentrated on targeting PARP1 and PARP2 at various phases of development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PARP inhibitors have demonstrated breakthrough advancements in the treatment of mCRPC; however, challenges such as resistance and the need for personalized therapies persist. Future research should emphasize target identification and the exploration of combination therapy strategies to enhance clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71298","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:37:12Z","timestamp":1761827832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>PARP<\/scp>\n                    Inhibitors in the Treatment of Prostate Cancer: An Analysis of the Clinical Trial Landscape"],"prefix":"10.1002","volume":"14","author":[{"given":"Yanru","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan China"},{"name":"North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Cao","sequence":"additional","affiliation":[{"name":"Affiliated 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Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianliang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering Faculty of Engineering, The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiebin","family":"Xie","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan 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