{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:31:31Z","timestamp":1772987491721,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long non\u2010coding RNA (lncRNA) H19 plays a pivotal role in the pathogenesis of different human cancers, but its role in soft tissue sarcoma (STS) has not yet been defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed H19 expression patterns in various cancer cell lines, focusing on sarcoma subtypes. RNA in\u00a0situ hybridization was performed on a tissue microarray (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009150) to assess H19 expression in human STS samples. Univariate and multivariate analyses were conducted to evaluate H19's prognostic value. In STS cell lines with high H19 expression, a Gapmer\u2010based knock\u2010down approach was used to study the functional\u00a0impact of H19 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Low H19 expression was associated with poor prognosis in univariate analysis (HR: 0.564; 95% CI: 0.324\u20130.985;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). Multivariate analysis showed advanced patient age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and large tumor size (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) as independent predictors of worse overall survival, irrespective of H19 expression (HR: 0.655; 95% CI: 0.367\u20131.170;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.153). H19 knockdown in STS cell lines reduced\u00a0cellular growth and increased pro\u2010apoptotic activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest that H19 might play a role in STS pathogenesis. While its prognostic value requires further investigation, H19\u2010based targeting approaches may warrant evaluation for therapeutic potential in STS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71305","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T03:24:46Z","timestamp":1768188286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance and Therapeutic Potential of Long Non\u2010Coding RNA H19 in Soft Tissue Sarcoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-0274","authenticated-orcid":false,"given":"Stephan","family":"Jahn","sequence":"first","affiliation":[{"name":"Diagnostic and Research Institute of Pathology, Comprehensive Cancer Center, Subunit Sarcoma Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Krajina","sequence":"additional","affiliation":[{"name":"Translational Oncology, II. Med Clinics University of Augsburg  Augsburg Germany"},{"name":"InLEC \u2013 Interdisciplinary Laboratory for Experimental Cancer Research University of Augsburg  Augsburg Germany"},{"name":"Research Unit for Non\u2010Coding RNA and Genome Editing, Division of Oncology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-0899","authenticated-orcid":false,"given":"Maria Anna","family":"Smolle","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimyana","family":"Neufeldt","sequence":"additional","affiliation":[{"name":"Translational Oncology, II. Med Clinics University of Augsburg  Augsburg Germany"},{"name":"InLEC \u2013 Interdisciplinary Laboratory for Experimental Cancer Research University of Augsburg  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Jonas","sequence":"additional","affiliation":[{"name":"Research Unit for Non\u2010Coding RNA and Genome Editing, Division of Oncology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Rinner","sequence":"additional","affiliation":[{"name":"Division of Biomedical Research Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Mellert","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-5630","authenticated-orcid":false,"given":"Maxim","family":"Noeparast","sequence":"additional","affiliation":[{"name":"Translational Oncology, II. Med Clinics University of Augsburg  Augsburg Germany"},{"name":"InLEC \u2013 Interdisciplinary Laboratory for Experimental Cancer Research University of Augsburg  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Trepel","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology University Medical Center Augsburg  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Szkandera","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Pichler","sequence":"additional","affiliation":[{"name":"Translational Oncology, II. 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