{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:32:26Z","timestamp":1780641146994,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Guidelines recommend starting average\u2010risk colorectal cancer (CRC) screening at age 45\u2009years, and thereafter repeating screening tests at regular intervals. However, US screening rates are currently suboptimal. This study evaluated adherence to repeat CRC screening with the non\u2010invasive multi\u2010target stool DNA (mt\u2010sDNA) test among US adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective claims\u2010based analysis of individuals aged 45\u201375\u2009years at average risk for CRC who had previously completed the mt\u2010sDNA test. Individuals received the repeat mt\u2010sDNA kit based on a point\u2010of\u2010care order. The primary outcome was adherence, defined as the return of a kit with a valid result within 1\u2009year. Secondary outcomes included rates of follow\u2010up colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 352,253 patients. Most patients were female (62.1%), White (60.9%), had no comorbidities (76.5%), and underwent one earlier mt\u2010sDNA test (98.1%). Overall adherence for repeat screening was 86.2%. In logistic regression analysis, higher household income ($100,000\u2013$200,000: 2.05; 1.49\u20132.77; &gt;\u2009$200,000: 2.46; 1.75\u20133.40; both vs.\u2009&lt;\u2009$25,000) and receipt of digital outreach (1.36; 1.33\u20131.40 vs. no digital communications) were associated with higher adherence to repeat screening. Mean (95% CI) time to a successful result was 35.6 (35.4\u201335.7) days. Among patients who tested positive, 75.8% underwent colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world study, adherence to repeat screening with the mt\u2010sDNA test was high. These findings underscore the effectiveness of the mt\u2010sDNA test in improving CRC screening adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71314","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:14:31Z","timestamp":1761804871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Adherence to Repeat Colorectal Cancer Screening With the Multi\u2010Target Stool\n                    <scp>DNA<\/scp>\n                    Test in a Large, Insured, and Average\u2010Risk Population"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-5483","authenticated-orcid":false,"given":"Mallik","family":"Greene","sequence":"first","affiliation":[{"name":"Exact Sciences Corporation  Madison Wisconsin 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