{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:09:10Z","timestamp":1791770950703,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Gastric cancer (GC) remains a major cause of cancer\u2010related mortality worldwide, driven by late\u2010stage diagnoses and poor survival outcomes. Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) are increasingly recognized as critical players in GC pathophysiology, though their exact roles are not fully understood. LIF, a multifunctional cytokine in the interleukin\u20106 family, signals through the LIFR\/gp130 complex and activates oncogenic pathways such as JAK\/STAT3, MAPK\/ERK, and Hippo\u2010YAP. Emerging evidence indicates that LIF drives tumor progression by promoting epithelial\u2013mesenchymal transition, immune evasion, and chemoresistance. Clinically, high LIF expression is associated with poor prognosis, peritoneal metastasis, and resistance to chemotherapy and immunotherapy. This review explores the molecular mechanisms of LIF\/LIFR signaling in GC, highlighting its potential as a prognostic biomarker and therapeutic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Mini Abstract Conclusion<\/jats:title>\n                    <jats:p>The LIF\/LIFR pathway contributing to gastric cancer is complex with context\u2010dependent pro\u2010 versus anti\u2010tumorigenic roles in GC progression, marking it as a significant biomarker and target for future therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71315","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:33:31Z","timestamp":1761806011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>LIF<\/scp>\n                    \/\n                    <scp>LIFR<\/scp>\n                    Signaling in Gastric Cancer: A Double\u2010Edged Sword in Tumor Progression and Therapeutic Resistance"],"prefix":"10.1002","volume":"14","author":[{"given":"Daniel","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of California San Francisco \u2013 Fresno Campus  Fresno California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaiser Permanente Inland Empire  Fontana California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yate\u2010Ching","family":"Yuan","sequence":"additional","affiliation":[{"name":"Translational Bioinformatics Center for Informatics City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranati","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Loma Linda University  Loma Linda California 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