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Cox proportional hazards models and logistic regression analyses were used to assess associations between medication use and overall survival, progression\u2010free survival and grade \u2265\u20093 adverse events. Analyses were adjusted for demographic, cancer and comorbidity factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Proton pump inhibitor use was associated with poorer overall survival (HR 1.19, 95% CI: 1.08\u20131.30), progression\u2010free survival (HR 1.11, 95% CI: 1.02\u20131.21) and an increased risk of grade \u2265\u20093 adverse events (OR 1.36, 95% CI: 1.21\u20131.53). Beta\u2010blockers, ACE inhibitors\/ARBs and calcium channel blockers were linked with higher adverse event rates but showed no significant impact on survival. Statins and metformin demonstrated no significant associations with either survival or adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings emphasise the need for careful management of concomitant medications in breast cancer care and support ongoing research to optimise treatment safety and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71320","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:21:38Z","timestamp":1761805298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Commonly Used Concomitant Medications With Survival and Adverse Event Outcomes in Breast Cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Natansh 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