{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:30:32Z","timestamp":1777865432058,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010acting somatostatin analogues (LA SSAs) are commonly used as first\u2010line treatment in well\u2010differentiated low and intermediate grade 1\u20132 gastroenteropancreatic neuroendocrine tumours (GEP\u2010NETs). As a long\u2010term treatment option for NETs, treatment preferences should be taken into consideration. The objective of this study is to evaluate the relative importance of different LA SSA treatment features among patients with NETs, clinicians and nurses in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A discrete choice experiment (DCE) method was used to analyse treatment preferences for NETs, embedded in an online survey. Participants could choose between three hypothetical treatment options: \u2018deep subcutaneous injectable treatment\u2019, \u2018deep intramuscular injectable treatment\u2019, \u2018oral treatment\u2019; and an opt\u2010out. Each option was described by seven attributes: \u2018Progression free survival\u2019 (PFS), \u2018symptom control for diarrhoea and flushing\u2019, \u2018risk of gastrointestinal (GI) side effects\u2019, \u2018frequency of administration\u2019, \u2018treatment administration,\u2019 \u2018treatment delivery,\u2019 and \u2018availability of patient support\u2019. A Mixed Multinomial Logit model (MMNL) was used for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 54 patients with NETs, 27 clinicians, and 9 nurses completed the DCE (of 33, 26 and 20 planned respectively). The statistical model showed an overall preference for oral administration. \u2018PFS\u2019 was the most important attribute, followed by \u2018symptom control for diarrhoea and flushing\u2019 and \u2018risk of GI side effects\u2019. \u2018PFS\u2019 and \u2018symptom control for diarrhoea and flushing\u2019 were also found to be more important to healthcare professionals (HCPs, i.e., clinicians and nurses) than patients with NETs, while the attributes \u2018symptom control for diarrhoea and flushing\u2019 and \u2018risk of GI side effects\u2019 were found to be more important in non\u2010metropolitan areas (vs. metropolitan areas).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Analysis showed how patients with NETs and HCPs prioritise treatment attributes for NETs differently. Because the duration of use of LA SSA for the treatment of NETs is often long, these differences highlight the importance of involving the patient when making treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71323","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:21:26Z","timestamp":1762946486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attribute Preferences for Somatostatin Analogues in Neuroendocrine Tumours (\n                    <scp>NETs<\/scp>\n                    ) Among Patients, Clinicians and Nurses in Australia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5221-0067","authenticated-orcid":false,"given":"Simon J.","family":"Fifer","sequence":"first","affiliation":[{"name":"Community and Patient Preference Research (CaPPRe)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Winkler","sequence":"additional","affiliation":[{"name":"Community and Patient Preference Research (CaPPRe)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Cummins","sequence":"additional","affiliation":[{"name":"NeuroEndocrine Cancer Australia  Blairgowrie Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima","family":"Cherian","sequence":"additional","affiliation":[{"name":"Ipsen Australia  South Yarra Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86839-2"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.09.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2015.002980"},{"key":"e_1_2_13_5_1","unstructured":"Cancer Australia \u201cNeuroendocrine Tumours Statistics 2023 \u201dhttps:\/\/www.canceraustralia.gov.au\/cancer\u2010types\/neuroendocrine\u2010tumours\/statistics."},{"key":"e_1_2_13_6_1","unstructured":"Australian Institute of Health and Welfare \u201cReports & Data 2023 \u201dhttps:\/\/www.aihw.gov.au\/."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123049"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6424812"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.304"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02060-1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0519"},{"issue":"6","key":"e_1_2_13_13_1","first-page":"4","article-title":"Patient Preference Methods\u2014A Patient Centered Evaluation Paradigm","volume":"13","author":"Bridges J.","year":"2007","journal-title":"ISPOR Connections"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-8-64"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-018-0305-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dis.2004.7.161"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.542"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2008.07.054"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/1312067-200801040-00009"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200826080-00004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1697"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-018-0734-2"},{"key":"e_1_2_13_23_1","unstructured":"The PREFER Consortium \u201cPREFER Recommendations: Why When and How to Assess and Use Patient Preferences in Medical Product Decision\u2010Making \u201dZenodo(2022)."},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.11.013"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01441640902827623"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0070288"},{"key":"e_1_2_13_27_1","unstructured":"D.McFadden \u201cConditional Logit Analysis of Qualitative Choice Behavior\u201d (1973)."},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/259131"},{"issue":"1","key":"e_1_2_13_29_1","first-page":"11","article-title":"On the Design and Analysis of Simulated Choice or Allocation Experiments in Travel Choice Modelling","volume":"890","author":"Louviere J. 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