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In this study, our aim was to analyze the impact of risk factors on the trends of compliance and detection rates in colonoscopy among high\u2010risk individuals aged 60\u201374.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted on the high\u2010risk individuals aged 60\u201374 participating in the 2021 CRC screening program in Tianjin, China. Logistic regression analyses, including both univariate and multivariate analyses, were performed to explore the impact of different risk factors on colonoscopy compliance among the high\u2010risk individuals. Besides, the study investigated the influence of various risk factors on the detection rates of bowel\u2010related diseases among the high\u2010risk individuals who underwent colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24,064 high\u2010risk individuals were included, and 5478 individuals received a free colonoscopy, with an overall compliance of 22.76%. Among them, the adenoma detection rate was 55.46%. Males and individuals with a positive FIT had high compliance and detection rates for CRC, advanced adenomas (AA), advanced colorectal neoplasia (ACN), and colorectal neoplasm (CN). Individuals aged 70\u201374 were associated with low compliance but high CRC, ACN, and CN detection rates. Individuals who reported a history of chronic constipation, bloody mucous, and CRC in first\u2010degree relative showed high compliance but no significantwere associated with the detection rates of CRC, AA, and CN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study reported several risk factors associated with the screening behaviors for CRC. Patterns and trends in CRC, AA, ACN, and CN compliance and detection rates correlate with risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7133","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T06:38:15Z","timestamp":1713422295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trends in colorectal cancer screening compliance and incidence among 60\u2010 to 74\u2010year\u2010olds in China"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-2026","authenticated-orcid":false,"given":"Mingqing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Tianjin Union Medical Center  Tianjin China"},{"name":"Nankai University School of Medicine Nankai University  Tianjin China"},{"name":"Tianjin Institute of Coloproctology  Tianjin China"},{"name":"The Institute of Translational Medicine, Tianjin 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