{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:43:11Z","timestamp":1788158591535,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Symptom management in myeloproliferative neoplasms (MPN) remains challenging despite advancements in disease\u2010directed therapies. This study assessed the impact of demographic, clinical, laboratory and treatment\u2010related variables on total symptom scores (TSS) and individual symptom scores in patients with polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of 553 patients (PV: 200; ET: 190; MF: 163) was identified through a retrospective chart review. Symptom scores, demographic information and clinical variables were captured at the time of the first TSS assessment. Laboratory results within 1\u2009month and treatment information within 90\u2009days prior to the symptom assessment were captured. Univariable linear regression, followed by multivariable regression analyses using a robust variance estimator were performed, with a\n                      <jats:italic>p<\/jats:italic>\n                      value &lt;\u20090.05 indicating a significant association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MF patients experienced the highest symptom burden and fatigue was the most reported symptom across all MPN subtypes. In PV, depression (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 10.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) was associated with a higher TSS whereas older age (\u22120.17; 0.01) and higher hemoglobin (\u22121.24; 0.003) were associated with a lower TSS. In ET, depression (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 14.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was associated with a higher TSS,\u00a0whereas in MF, depression (12.28; &lt;\u20090.001) and higher WBC count (0.22; 0.02) were associated with a higher TSS. Depression and non\u2010White race in PV, depression in ET, and depression, low hemoglobin, and higher WBC count in MF were associated with multiple symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Integrating depression screening and management and optimizing hematologic parameters alongside disease\u2010directed therapy is crucial to improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71333","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T13:34:26Z","timestamp":1764423266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of Symptom Scores in Myeloproliferative Neoplasms: A Real\u2010World Retrospective Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0079-9935","authenticated-orcid":false,"given":"Muhammad Ali","family":"Khan","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Arsalan Ahmed","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Camoriano","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-5140","authenticated-orcid":false,"given":"Cecilia Y.","family":"Arana Yi","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Andres","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Blocher","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi E.","family":"Kosiorek","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-1504","authenticated-orcid":false,"given":"Jeanne M.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695957"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2022.101372"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22365"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.01.035"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.3863"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0046"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-170449"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02524-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-183005"},{"issue":"3","key":"e_1_2_11_12_1","first-page":"175","article-title":"Myeloproliferative Neoplasm Symptom Assessment Total Symptom Score (MPN\u2010SAF TSS) in Chronic Myeloproliferative Neoplasms With Relation to Genetic Burden and Thrombosis","volume":"41","author":"\u00dcmit E. 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