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Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates. Natural medicines, as key elements of complementary and alternative medicine, exhibit considerable potential in combating hematological cancers. Particularly when used in combination with conventional therapies, they can enhance treatment efficacy and reverse drug resistance. This review comprehensively summarizes the mechanisms of action of bioactive natural compounds, extracts, and derivatives against hematological malignancies, with a focus on their roles in apoptosis induction, proliferation suppression, autophagy regulation, cell cycle arrest, and chemosensitization. We also consolidate evidence from preclinical studies and clinical cases supporting their combined use with standard treatments. By elucidating the therapeutic potential and mechanistic insights of natural medicines, this review aims to provide a foundation for developing more effective and safer treatment strategies, facilitating the translation of natural product\u2010based therapies into clinical practice for hematological malignancies.<\/jats:p>","DOI":"10.1002\/cam4.71335","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:17:39Z","timestamp":1763043459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine"],"prefix":"10.1002","volume":"14","author":[{"given":"Yaoyao","family":"Tian","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"The First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Ni","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"The First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Cai","sequence":"additional","affiliation":[{"name":"Harbin Vocational and Technical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Hongqi Hospital of Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"The First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Song","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuyi County People's Hospital  Huai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1354-5127","authenticated-orcid":false,"given":"Jiakang","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac095"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1036498"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-00882-9"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354241302049"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1218467"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14441"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04463-7"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.811850"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55574"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23580"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203252"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34618"},{"key":"e_1_2_16_17_1","first-page":"1706","article-title":"Effect of Baicalin on Pyroptosis of Diffuse Large B\u2010Cell Lymphoma Cell Lines DB and Its Mechanism","volume":"31","author":"Lu M.","year":"2023","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_16_18_1","first-page":"730","article-title":"Regulation of Baicalin on Growth of Extranodal NK\/T Cell Lymphoma Cells Through FOXO3\/CCL22 Signaling Pathway","volume":"31","author":"Duan X. 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