{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:30:18Z","timestamp":1777865418481,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Gastrointestinal stromal tumor (\n GIST<\/jats:styled-content>\n ) occurs predominantly in the elderly population. However, clinical data on the outcomes of treatment with imatinib in elderly patients are limited. The aim of this study was to determine the efficacy and safety of imatinib for advanced\n GIST<\/jats:styled-content>\n in the elderly population compared with the non\u2010elderly population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed the clinical data of patients who received imatinib as first\u2010line treatment for advanced\n GIST<\/jats:styled-content>\n at our hospital between January 2010 and July 2023. Progression\u2010free survival (\n PFS<\/jats:styled-content>\n ), overall survival (\n OS<\/jats:styled-content>\n ), and adverse events were compared between elderly patients (age\u2009\u2265\u200970\u2009years, E group) and non\u2010elderly patients (age\u2009<\u200970\u2009years,\n NE<\/jats:styled-content>\n group).\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Data of 91 patients (E group,\n n<\/jats:italic>\n \u2009=\u200932;\n NE<\/jats:styled-content>\n group,\n n<\/jats:italic>\n \u2009=\u200959) with a median follow\u2010up of 39.8\u2009months were analyzed. A significantly higher proportion of patients in the E group required a reduced starting dose of imatinib (34% vs. 2%,\n p<\/jats:italic>\n \u2009<\u20090.001). Median\n PFS<\/jats:styled-content>\n was 29.4\u2009months in the E group and 60.0\u2009months in the\n NE<\/jats:styled-content>\n group (hazard ratio [\n HR<\/jats:styled-content>\n ] 2.04,\n p<\/jats:italic>\n \u2009=\u20090.04, log\u2010rank test); median\n OS<\/jats:styled-content>\n was 91.5\u2009months in the E group and not reached in the\n NE<\/jats:styled-content>\n group (\n HR<\/jats:styled-content>\n 2.72,\n p<\/jats:italic>\n \u2009=\u20090.03, log\u2010rank test). Multivariable analysis identified age as an independent prognostic factor for\n PFS<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 2.26,\n p<\/jats:italic>\n \u2009=\u20090.03) and a trend towards worse\n OS<\/jats:styled-content>\n with increasing age (\n HR<\/jats:styled-content>\n 2.93,\n p<\/jats:italic>\n \u2009=\u20090.06). Grade 2 or higher non\u2010hematological adverse events were more prevalent in the E group (78% vs. 32%,\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Imatinib is an effective treatment for advanced\n GIST<\/jats:styled-content>\n in elderly patients. However, elderly patients were associated with poorer efficacy and a Higher incidence of toxicities due to imatinib compared with non\u2010elderly patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.71338","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:50:19Z","timestamp":1761911419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Analysis of the Efficacy and Safety of Imatinib for Advanced Gastrointestinal Stromal Tumor in Elderly Patients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9512-087X","authenticated-orcid":false,"given":"Takahito","family":"Awatsu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Tokyo Japan"},{"name":"Department of Gastroenterology Juntendo University, School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-9045","authenticated-orcid":false,"given":"Kengo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Clinical and Translational Research Center Keio University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer 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