{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:06Z","timestamp":1791996126878,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chemotherapy is crucial in treating gestational trophoblastic neoplasia (GTN), but its impact on gonadotoxicity is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This case\u2013control study included 57 GTN patients and 19 age\u2010matched patients with molar pregnancies (MP) in 2012\u20132018. Multiples of the median (MoM) of the serum AMH levels were compared between the two groups, and between patients using single\u2010agent and combination chemotherapy, at baseline, 6, 12, and 24\u2009months after treatment. Their pregnancy outcomes were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the MoM of serum AMH between GTN and MP groups at all time points. Single\u2010agent chemotherapy did not adversely affect the MoM. However, those receiving combination chemotherapy had lower MoM than those receiving single\u2010agent chemotherapy at all time points. The trend of decline from the baseline was marginally significant in patients with combination chemotherapy, but the drop was only significant at 12\u2009months (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u22122.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) but not at 24\u2009months (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u22121.90; <jats:italic>p<\/jats:italic>\u2009=\u20090.058). Multivariable analysis revealed that combination chemotherapy did not affect the MoM. There was no significant difference in the 4\u2010year pregnancy rate and the livebirth rate between the single\u2010agent and combination groups who attempting pregnancy, but it took 1\u2009year longer to achieve the first pregnancy in the combination group compared to the single\u2010agent group (2.88 vs. 1.88\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed combination chemotherapy led to a decreasing trend of MoM of serum AMH especially at 12\u2009months after treatment, but the drop became static at 24\u2009months. Although pregnancy is achievable, thorough counseling is still needed in this group especially those wish to achieve pregnancy 1\u20132\u2009years after treatment or with other risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7134","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T08:50:16Z","timestamp":1711615816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the multiples of the median of serum anti\u2010m\u00fcllerian hormone and pregnancy outcomes in patients with gestational trophoblastic disease: A case\u2013control study"],"prefix":"10.1002","volume":"13","author":[{"given":"Theodora Hei Tung","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley Suk Kwan","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, School of Clinical Medicine  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Fei","family":"Ngu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Mary Hospital  Hong Kong China"},{"name":"Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, School of Clinical Medicine  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-0147","authenticated-orcid":false,"given":"Man Yee Mandy","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Mary Hospital  Hong Kong China"},{"name":"Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, School of Clinical Medicine  Hong Kong 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Gynaecological Oncology, Department of Obstetrics and Gynaecology, School of Clinical Medicine  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Hang Wun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Mary Hospital  Hong Kong China"},{"name":"Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, School of Clinical Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-0970","authenticated-orcid":false,"given":"Ka Yu","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Mary Hospital  Hong Kong China"},{"name":"Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, School of Clinical Medicine  Hong Kong 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