{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:31:14Z","timestamp":1772987474176,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Darolutamide plus androgen\u2010deprivation therapy (ADT) improved metastasis\u2010free survival (MFS) by 2\u2009years and reduced the risk of death by 31% in nonmetastatic castration\u2010resistant prostate cancer (nmCRPC) in ARAMIS. Prior local therapy may influence the efficacy of subsequent systemic therapy. This post hoc analysis of ARAMIS evaluated the effect of prior local therapy on the efficacy and health\u2010related quality of life (HRQoL) of darolutamide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with nmCRPC were randomized to darolutamide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009955) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009554) while continuing ADT. MFS, overall survival (OS), time to prostate\u2010specific antigen (PSA) progression, and HRQoL deterioration\u2010free survival (DetFS) were estimated for patients with and without local therapy and by treatment using Kaplan\u2013Meier methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Darolutamide increased MFS versus placebo in patients with (HR, 0.36; 95% CI, 0.26\u20130.48) and without (HR, 0.46; 95% CI, 0.36\u20130.59) local therapy. Median OS was 48.6\u2009months for placebo without local therapy and not reached in either the darolutamide group or placebo group with local therapy. Darolutamide 3\u2010year OS rates were 86.9% (95% CI, 83.0\u201390.8) and 79.0% (95% CI, 66.2\u201378.1) in patients with and without local therapy, respectively. Darolutamide showed evidence of improved OS versus placebo in patients with prior local therapy (HR, 0.80; 95% CI, 0.50\u20131.30) and a greater effect in those without local therapy (HR, 0.67; 95% CI, 0.50\u20130.90). Darolutamide delayed time to PSA progression and HRQoL deterioration regardless of local therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Darolutamide versus placebo improved MFS, OS, time to PSA progression, and HRQoL DetFS independent of prior local therapy, consistent with the overall ARAMIS population.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov registration: NCT02200614\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71343","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:42:17Z","timestamp":1766738537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Prior Local Therapy by Radical Prostatectomy or Radiotherapy on the Efficacy and Quality of Life of Patients Treated With Darolutamide in ARAMIS"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-8056","authenticated-orcid":false,"given":"Matthias","family":"Saar","sequence":"first","affiliation":[{"name":"Department of Urology and Pediatric Urology University Medical Center RWTH Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Fizazi","sequence":"additional","affiliation":[{"name":"Institut Gustave Roussy University of Paris Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal D.","family":"Shore","sequence":"additional","affiliation":[{"name":"Carolina Urologic Research Center  Myrtle Beach South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Smith","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Erik","family":"Damber","sequence":"additional","affiliation":[{"name":"University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Semenov","sequence":"additional","affiliation":[{"name":"Ivanovo Regional Oncology Dispensary  Ivanovo Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Ribal","sequence":"additional","affiliation":[{"name":"Uro\u2010Oncology Unit, Hospital Clinic University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Birtle","sequence":"additional","affiliation":[{"name":"Rosemere Cancer Centre Lancashire Teaching Hospitals  Preston UK"},{"name":"University of Manchester  Manchester UK"},{"name":"University of Central Lancashire  Preston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Rigaud","sequence":"additional","affiliation":[{"name":"Nantes University Hospital Centre  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J. D.","family":"Wallis","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Oliver","family":"Grimm","sequence":"additional","affiliation":[{"name":"Jena University Hospital  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Halabi","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University Department of Medicine, Division of Medical Oncology  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ateesha F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Bayer Consumer Care AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Adorjan","sequence":"additional","affiliation":[{"name":"Duke University Division of Biostatistics  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankar","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Bayer HealthCare Pharmaceuticals Inc.  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