{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:30:34Z","timestamp":1777865434759,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403398"],"award-info":[{"award-number":["82403398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Single nucleotide polymorphisms (SNPs) located in the genes participating in the steroid hormone metabolism pathway may influence the outcomes of androgen deprivation therapy (ADT) in prostate cancer (PCa) patients, but findings on the Chinese population remain limited.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multicentric cohort of 301 Chinese PCa patients receiving first\u2010line ADT was enrolled. Germline SNPs located in 62 steroid hormone metabolism\u2010related genes were analyzed for associations with time to ADT failure using multivariate Cox regression. Important expression quantitative trait loci (eQTLs) were discovered.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Four SNPs were significantly associated with time to ADT failure: rs36119043 in\n AKR1D1<\/jats:italic>\n (hazard ratio, HR\u2009=\u20092.02, 95% confidence interval, 95% CI: 1.44\u20132.85,\n p<\/jats:italic>\n \u2009=\u20095.72\u2009\u00d7\u200910\n \u22125<\/jats:sup>\n ), rs151155810 in\n HSD17B12<\/jats:italic>\n (HR\u2009=\u20097.87, 95% CI: 2.78\u201322.30,\n p<\/jats:italic>\n \u2009=\u20091.05\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n ), rs71179009 in\n SULT2B1<\/jats:italic>\n (HR\u2009=\u20092.16, 95% CI: 1.44\u20133.22,\n p<\/jats:italic>\n \u2009=\u20091.85\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n ), rs28609134 in\n SRD5A3<\/jats:italic>\n (HR\u2009=\u20092.50, 95% CI: 1.51\u20134.15,\n p<\/jats:italic>\n \u2009=\u20093.79\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n ). Potential causal eQTLs in the LD regions of these SNPs were identified, with significant impacts on\n AKR1D1<\/jats:italic>\n ,\n SULT2B1<\/jats:italic>\n , and\n SRD5A3<\/jats:italic>\n expression in diverse tissues. A cumulative risk allele effect was observed: HR\u2009=\u20092.74 (95% CI: 1.86\u20134.03) under the dominant model and HR\u2009=\u20092.04 (95% CI: 1.63\u20132.55) under the additive model, with a median survival of 176\u2009months (95% CI: N\/A) in noncarrier patients vs. 92\u2009months (95% CI: 65\u2013N\/A) in one risk locus\u2010carriers and 55\u2009months (95% CI: 26\u2013N\/A) in two risk loci\u2010carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SNPs in the steroid hormone metabolism pathway can predict time to ADT failure in Chinese PCa patients, supporting their potential role for drug response and pharmacogenomic stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.71351","type":"journal-article","created":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:13:56Z","timestamp":1762103636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Germline Single Nucleotide Polymorphisms in Steroid Hormone Metabolism Pathway With Androgen Deprivation Therapy Prognosis of Prostate Cancer in Chinese Population"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1001-390X","authenticated-orcid":false,"given":"Ruofan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-5237","authenticated-orcid":false,"given":"Xiaohao","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsun Tsun Stacia","family":"Chun","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang Philip","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsz Yeung","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-5108","authenticated-orcid":false,"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS 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