{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:11:47Z","timestamp":1790795507733,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      T\u2010cell lymphoblastic lymphoma (T\u2010\n                      <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                      ) is a rare non\u2010Hodgkin lymphoma. The World Health Organization defines T\u2010\n                      <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                      and T\u2010cell acute lymphoblastic leukemia (T\u2010\n                      <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                      ) as the same entity. However, the clinical variations between them result in divergent treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to compare the outcomes of patients with T\u2010LBL and T\u2010ALL and identify ideal candidates for autologous hematopoietic stem cell transplantation (auto\u2010HSCT) or allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This retrospective analysis included 148 patients diagnosed with T\u2010LBL (67 [45.3%]) or T\u2010ALL (81 [54.7%]) between November 2009 and December 2022 in seven hospitals in the Republic of Korea. Overall survival (OS) and progression\u2010free survival (PFS) were analyzed using the Kaplan\u2013Meier method, and allo\u2010HSCT, auto\u2010HSCT, and chemotherapy\u2010only treatment modalities were compared. Cox proportional hazards models were used to identify risk factors for survival, and survival decision trees were used for risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up duration was 60\u2009months. The 5\u2010year OS rates were 43.5% and 52.8% in the T\u2010LBL and T\u2010ALL groups, respectively (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.111). The T\u2010LBL group had lower PFS than the T\u2010ALL group (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001). The 5\u2010year OS rates for allo\u2010HSCT, auto\u2010HSCT, and chemotherapy\u2010only were 62.8%, 62.4%, and 13%, respectively. Two or more extranodal sites, large masses &gt;\u20096\u2009cm, axial bone involvement, and non\u2010complete remission after chemotherapy were poor prognostic factors for OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicenter retrospective analysis, hematopoietic stem\u2010cell transplantation (allo\u2010 or auto\u2010HSCT) was associated with better survival than chemotherapy alone. For T\u2010LBL, an exploratory signal from our prognostic model suggests that selected high\u2010risk patients may be considered for upfront allo\u2010HSCT. However, overall survival was comparable between allo\u2010 and auto\u2010HSCT in this cohort, and durable outcomes after transplant were largely observed in patients who achieved complete remission. These findings are hypothesis\u2010generating and support individualized, response\u2010adapted strategies that warrant prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71365","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:00:37Z","timestamp":1765630837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk Factors Influencing Survival in T\u2010Cell Lymphoblastic Lymphoma and T\u2010Cell Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-992X","authenticated-orcid":false,"given":"Tong Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Hematology, Yeoido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung 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