{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:30:17Z","timestamp":1777865417819,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present reproductive and oncological outcomes of radical trachelectomy (RT) in patients with cervical adenocarcinomas (AC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 51 patients with cervical AC who underwent RT at Peking Union Medical Hospital from January 1, 2005 to June 1, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five patients (9.8%) experienced cervical stenosis following RT, which likely occurred in cases of abdominal RT (50%) and virginal prophylactic cerclage (33.33%) and those without copper T intrauterine devices during RT (20%). In total, 30 patients (58.82%) attempted to conceive, and 11 (36.67%) succeeded. Five patients (45.45%) achieved pregnancy with fertility assistance. The mean surgery\u2013pregnancy interval was 27 months (range, 17\u2013118). Two preterm and two full\u2010term births were achieved. With a median follow\u2010up of 50 months (range, 7\u2013238), seven patients (13.73%) experienced recurrence and three (5.88%) died. Six of seven patients relapsed beyond the residual cervix. The cancer recurrence rate (CRR) was 5.88% for patients with pre\u2010cervical conization and 17.65% for those with biopsy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.250); 11.63% had human papillomavirus\u2010associated (HPVA) disease and 25% had non\u2010HPVA (NHPVA)\u00a0(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.313). The cancer death rate (CDR) was 4.65% with HPVA and 12.50% with NHPVA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.386); 13.63% had the endogenous type and 0 had the exogenous type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Chemotherapy in patients with risk factors resulted in better CRR and CDR than in those without (5.88% vs. 17.65%, 0% vs. 8.82%). The cumulative 5\u2010year recurrence\u2010free survival (RFS) and overall survival rates were 82.03% and 94.39%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RT in patients with AC led to an acceptable pregnancy rate but a higher CRR and lower 5\u2010year RFS. Careful patient selection for RT, combined with adjuvant chemotherapy when indicated, is crucial to optimize the balance between reproductive and oncological outcomes in AC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71366","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:25:11Z","timestamp":1762590311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Adenocarcinoma: What's Special About the Long\u2010Term Reproductive and Oncological Outcomes of Fertility\u2010Sparing Radical Trachelectomy in It?"],"prefix":"10.1002","volume":"14","author":[{"given":"Jingwen","family":"Gan","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital (Dongdan Campus)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-832X","authenticated-orcid":false,"given":"Dongyan","family":"Cao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital (Dongdan Campus)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimei","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital (Dongdan Campus)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital (Dongdan Campus)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital (Dongdan Campus)  Beijing 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