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While METTL14 plays a crucial role in cancer, its regulation of immune\u2010 and inflammation\u2010related genes remains poorly understood. This study aims to investigate whether METTL14 is involved in regulating the expression of genes associated with tumor necrosis factor (TNF), interferon (IFN), interleukin (IL), and MHC class I in NPC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) and Western blotting were used to examine METTL14 expression in NPC cells with either shMETTL14 knockdown or METTL14 overexpression. RNA sequencing was performed to identify differentially expressed genes associated with TNF, IFN, IL, and MHC class I in NPC cells, and qRT\u2010PCR was used to validate the expression of these genes. A cytokine production assay was conducted to measure the levels of TNFSF9, IFI16, IL\u20106, IL\u20107, CXCL10, and HLA\u2010B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our study demonstrates that METTL14 potentially plays a fundamental role in modulating the expression of genes associated with TNF, IFN, IL, and MHC class I in NPC cells. RNA sequencing of NPC cells showed that METTL14 upregulated or downregulated several genes associated with immunity and inflammation, including TNF, IFN, IL, and MHC class I. RNA interference\u2010mediated knockdown of METTL14 revealed its regulatory effects on TNF\u2010related genes (e.g., TNFRSF12A, TNFRSF9, TNFSF15), IFN\u2010induced genes (e.g., PSMC6, PSMD1, PSMA2, PSMA3, PSMB2), and IL\u2010related genes (e.g., CCL5, IL1B, IL32, IL7R, IL6, IL7, CXCL2). Furthermore, METTL14 was found to positively regulate MHC class I gene expression (e.g., HLA\u2010A, \u2010B, \u2010C, \u2010E, \u2010F) in NPC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate, for the first time, that METTL14 modulates the expression of genes related to TNF, IFN, IL, and MHC class I in NPC, proposing a novel role for METTL14 in linking inflammation with cancer, a function that has not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71371","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:29:37Z","timestamp":1764394177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>METTL14<\/scp>\n                    Regulates the Expression of Genes Related to Interferon, Interleukin and\n                    <scp>MHC<\/scp>\n                    Class I in Nasopharyngeal Carcinoma Cells"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhihao","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory Animal Management Center, Cancer Research Institute, School of Basic Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Management Center, Cancer Research Institute, School of Basic Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis Yunnan Clinical Medical Center for Infectious Diseases, the Third People's Hospital of Kunming (The Sixth Affiliated Hospital of Dali University)  Kunming 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