{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:50:05Z","timestamp":1793883005793,"version":"4.7.0"},"reference-count":27,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Oncotype DX Breast Recurrence Score test was designed for HR+, HER2\u2212 early breast cancer (eBC) to assist in the decision\u2010making process for de\u2010escalating adjuvant chemotherapy (CT). Its validity and utility have been demonstrated prospectively across multiple studies, though data on older patients remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included patients over 70\u2009years with eBC treated between 2018 and 2023 at Tenon Hospital, Paris, France. Characteristics of populations eligible for the test and those with RS \u2264 or &gt;\u200925 were collected, along with oncogeriatric assessment and treatments; statistical analysis was performed for IDFS and OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 365 patients &gt;\u200970\u2009years, mean age was 77.6\u2009years (range 70\u201396), with 84.4% diagnosed with HR+\/HER2\u2212 eBC. Oncotype DX testing was performed in 85 patients (27.9% of HR+\/HER2\u2212 eBC), revealing a Recurrence Score (RS) result &gt;\u200925 in 14 patients (15%). The RS\u2009&gt;\u200925 group had more grade 3 tumors, more pT2 tumors, and a higher Ki67\u2009&gt;\u200920%. In the RS\u2009&gt;\u200925 group, 9 patients (64%) had oncogeriatric consultations, and 7 (50%) started the recommended adjuvant CT. Four patients received taxane\u2010cyclophosphamide (TC) and 3 adriamycin\u2010cyclophosphamide\u2010taxane (AC\u2010T), with 2 discontinuing due to taxane\u2010induced neuropathy. Median IDFS was significantly lower in the RS\u2009&gt;\u200925 group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0023), with 4 of 5 recurrences occurring in patients who did not receive adjuvant CT. OS showed no significant difference by RS group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.87).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This observational study highlights that the Oncotype DX test supports therapeutic de\u2010escalation in patients with RS \u2264\u200925 and serves as a prognostic marker. Oncogeriatric evaluations are essential to guide adjuvant treatments in older breast cancer patients prior to using genomic signatures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71386","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:43:44Z","timestamp":1763642624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncotype Dx Breast Cancer Assay in Older Patients: A Real Life Cohort"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0234-4152","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Grosnon","sequence":"first","affiliation":[{"name":"Medical Oncology Department Institut Universitaire de Canc\u00e9rologie AP\u2010HP Sorbonne Universit\u00e9, Tenon Hospital  Paris 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Institut Universitaire de Canc\u00e9rologie AP\u2010HP Sorbonne Universit\u00e9, Tenon Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Nedelcu","sequence":"additional","affiliation":[{"name":"Gynaecology Department Institut Universitaire de Canc\u00e9rologie AP\u2010HP Sorbonne Universit\u00e9, Tenon Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolaine","family":"Le Gac","sequence":"additional","affiliation":[{"name":"Gynaecology Department Institut Universitaire de Canc\u00e9rologie AP\u2010HP Sorbonne Universit\u00e9, Tenon Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Jamelot","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Institut Universitaire de Canc\u00e9rologie AP\u2010HP Sorbonne Universit\u00e9, Tenon Hospital  Paris 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