{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:16:19Z","timestamp":1771334179382,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009826","name":"Harvey L. Neiman Health Policy Institute","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100009826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010embolization syndrome after transarterial chemoembolization (TACE) and Yttrium\u201090 radioembolization (TARE) causes significant morbidity. Understanding whether discharge prescriptions influence short\u2010term outcomes may guide standardized pain\u2010management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study of 3191 patients (3988 procedures) with hepatocellular carcinoma from the Merative MarketScan Databases (2009\u20132022) was performed. The composite outcome was 7\u2010day drug escalation or hospital readmission. Bivariate logistic regression identified candidate variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.10); multivariable logistic regression with patient\u2010clustered robust standard errors estimated adjusted odds ratios (aORs), adjusting for age, sex, and Charlson Comorbidity Index (CCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to patients discharged without opioids post\u2010chemoembolization, those prescribed opioids at discharge had 83% lower odds of experiencing drug escalation or readmission (odds ratio [aOR]\u2009=\u20090.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and those undergoing radioembolization had 59% lower odds (aOR\u2009=\u20090.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Being prescribed antiemetics or steroids was also associated with lower odds of escalation\/readmission events, with percentages varying by procedure type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prescribing opioids, along with antiemetics and steroids, at discharge may reduce the likelihood of post\u2010procedural events, such as drug escalation and readmission, in patients undergoing trans\u2010arterial chemoembolization and radioembolization for hepatocellular carcinoma. These findings highlight the importance of a comprehensive pain management strategy in interventional oncology and warrant consideration in clinical practice guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71418","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:49:18Z","timestamp":1764809358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Discharge Medications and Oncologic Post\u2010Embolization\u2010Syndrome\u2010Related Outcomes"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-5717","authenticated-orcid":false,"given":"Hanzhou","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Horn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"},{"name":"Department of Health Promotion and Policy, School of Public Health and Health Sciences University of Massachusetts Amherst  Amherst Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1837-6201","authenticated-orcid":false,"given":"Nicholas","family":"Lima","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menelaos","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"University of Toronto, Institute of Health Policy, Management and Evaluation  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Molecular and Interventional Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Benenati","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Gichoya","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Bercu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"StatPearls","author":"Asafo\u2010Agyei K. 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