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Tumor\u2010infiltrated T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009have emerged as key players in immune checkpoint blockade (ICB) therapy, contributing to early therapeutic responses and tumor control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This review aims to comprehensively summarize the identification, functional roles, and regulatory mechanisms of T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009in the context of tumor immunity, and to explore innovative strategies for enhancing T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2010mediated anti\u2010tumor responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed recent literature on T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009biology, focusing on their transcriptional regulation, phenotypic characteristics, and interactions within the tumor microenvironment. We also reviewed current strategies for modulating T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009function to improve cancer immunotherapy outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009can remodel the tumor microenvironment, suppress tumor progression, and enhance ICB efficacy. Their function is tightly regulated by transcription factors and phenotypic molecules. Targeted manipulation of these regulatory mechanisms has shown potential in enhancing T\n                      <jats:sub>RM<\/jats:sub>\n                      \/T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2010like cell activity and overcoming resistance to ICB therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      T\n                      <jats:sub>RM<\/jats:sub>\n                      \u2009represent a promising target for cancer immunotherapy due to their potent anti\u2010tumor functions and responsiveness to ICB. Understanding their biology and regulatory networks opens new avenues for therapeutic intervention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71429","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:27:45Z","timestamp":1765258065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tissue\u2010Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Yao","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-8013","authenticated-orcid":false,"given":"Zhi\u2010Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences Wuhan University  Wuhan China"},{"name":"Department of Oral Maxillofacial\u2010Head Neck Oncology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5871"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.007"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav5581"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0313180"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u20100333\u2010y"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010018\u20100114\u20102"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201605"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.018"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010023\u201001538\u20106"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adq4881"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.008"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.06.017"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.015"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.446"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090858"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1545"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9673"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.005"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003008"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010022\u201001229\u20108"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024734\u20100"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646837"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900052"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915681117"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201019\u20100554"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.009"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004888"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074\u20107613(04)00021\u20104"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402256"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010003329"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700571"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701474"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701272"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21379"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201019\u20100702"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add5976"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abn8390"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005072\u20100"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.001"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201002595\u2010z"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.133"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav5728"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.019"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3962"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108085"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000590\u20103"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191711"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201013\u20101877"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100812\u20109"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u20100111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