{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:15:54Z","timestamp":1771334154403,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) are often the initial treatment choice for melanoma, the third most common cancer in the adolescent and young adult (AYA) male population. Although ICIs have improved survival rates, their effects on male fertility and the adequacy of related counseling remain unclear. This study aimed to both characterize the current state of fertility discussions in male AYA patients with melanoma receiving first\u2010line ICIs and to explore their experiences and concerns regarding reproductive health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a mixed\u2010methods study of 38 male patients aged 18\u201339 with metastatic or locally advanced melanoma treated with first\u2010line PD\u20101\/PD\u2010L1\/CTLA\u20104 therapies at a single academic center between 2013 and 2024. Quantitative medical record review assessed fertility counseling and preservation actions. Semi\u2010structured interviews were conducted with ten living patients from this cohort to explore knowledge, concerns, and experiences surrounding fertility and reproductive health. Thematic analysis identified key patient perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 38 patients (median age 32), 71% had stage IV disease and received combination immunotherapy. 74% of patients experienced at least one immune\u2010related adverse event (irAE). Fertility counseling was documented for 27 patients, with eight referred for fertility preservation. Of the ten interviewees, nine recalled discussing fertility, while only three pursued preservation. Qualitative themes included challenges accepting uncertainty about family planning, pressure to accelerate planning, feelings of forced maturity, difficulty processing complex information, and concerns about the reliability of information from family, providers, and social media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although most young males with advanced melanoma treated with first\u2010line ICIs had documented fertility discussions, few elected fertility preservation. Patient experiences highlight the need for collaboration among oncologists, fertility specialists, and supportive professionals to develop tailored counseling and educational materials for male AYA patients with advanced melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71437","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T13:44:48Z","timestamp":1764423888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fertility Concerns and Outcomes Among Adolescent and Young Adult Males With Melanoma Receiving Immunotherapy: A Mixed\u2010Methods Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Haadi","family":"Ali","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0900-2275","authenticated-orcid":false,"given":"Ellen","family":"Wold","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Haykal","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dawood","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Wytiaz","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000344"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-4006-z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5349-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29871"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000038"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27445"},{"key":"e_1_2_12_8_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology: Cutaneous Melanoma. 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