{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:24:49Z","timestamp":1771899889436,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","award":["ALF\u20102023\u2010YF0030"],"award-info":[{"award-number":["ALF\u20102023\u2010YF0030"]}],"id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2024\u201003748"],"award-info":[{"award-number":["2024\u201003748"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","award":["20230633"],"award-info":[{"award-number":["20230633"]}],"id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS\u2010984649"],"award-info":[{"award-number":["SLS\u2010984649"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several case reports have recounted hiccups as a possible symptom of cancer, but potential associations in large study samples have not been examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population\u2010based cohort study examined associations between hiccups and subsequent cancer diagnoses. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 8466 patients diagnosed with hiccups during the study period (1997\u20132018), 7531 (89.0%) were men, 4013 (47.4%) were diagnosed in primary healthcare, and 325 (3.8%) were diagnosed with cancer. In men, hiccups were associated with nervous system (SIR 1.94; 95% CI, 1.08\u20133.20), hematologic (1.52; 1.17\u20131.93), and gastrointestinal (1.61; 1.36\u20131.89) cancers, including esophageal (2.63; 1.47\u20134.43), stomach (2.27; 1.42\u20133.45), colon (1.61; 1.23\u20132.08), and liver (1.77; 1.05\u20132.80) cancers. In women, hiccups were associated with gastrointestinal cancer (2.23; 1.27\u20133.63). Particularly strong associations were observed within 12\u2009months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings may be useful for clinical practice and could provide foundations for detailed clinical studies on hiccups as a potential clinical cancer marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71441","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:50:02Z","timestamp":1764510602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Hiccups and Subsequent Cancer Diagnoses: A Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-9996","authenticated-orcid":false,"given":"Filip","family":"Jans\u00e5ker","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-4657","authenticated-orcid":false,"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-279X","authenticated-orcid":false,"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2007.01612_4.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201310001-01339"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496332"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2242768"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010247830"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"246","article-title":"Hiccups and Oesophageal Malignancy","volume":"60","author":"McLoughlin J. 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