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Long non\u2010coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor malignancy mechanisms. Among these, small nucleolar host genes (SNHGs) represent a specific subgroup of lncRNAs that have recently been shown to be critically involved in the development of HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aims to summarize recent findings regarding the role of SNHGs in HCC carcinogenesis, and to clarify their mechanistic functions in cancer progression as well as their potential as diagnostic markers and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed in the PubMed database using the following keywords: \u201csmall nucleolar host gene\u201d, and \u201chepatocellular carcinoma\u201d, or \u201cliver cancer\u201d. Relevant literature was retrieved and screened to synthesize the latest research findings on the roles of SNHGs in HCC carcinogenesis. No restrictions were predefined on the publication time of the included literature, and studies focusing on the mechanistic insights and therapeutic potential of SNHGs in HCC were prioritized for inclusion in this narrative review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Abnormal expression of SNHGs in HCC affects many facets of the disease, including tumor cell proliferation, stemness, invasion, migration, apoptosis, autophagy, ferroptosis (an iron\u2010dependent form of cell death), and pyroptosis (a highly inflammatory form of programmed cell death), as well as metabolic processes such as glycolysis, lipid and cholesterol metabolism. Furthermore, these expressions can alter the tumor microenvironment and contribute to resistance against sorafenib, a common treatment for HCC. Numerous studies have further revealed SNHGs promote the onset and progression of HCC through competing endogenous RNA (ceRNA, different RNA molecules compete for same microRNAs) network. Additionally, recent research shows that non\u2010ceRNA mechanisms, including small nucleolar RNA (snoRNA) mediated regulation, epigenetic regulation, and modulation of mRNA stability, also contribute to SNHGs' regulation of HCC development and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNHGs play critical regulatory roles in HCC carcinogenesis and progression through both ceRNA and non\u2010ceRNA mechanisms. They hold potential as promising diagnostic markers and therapeutic targets for HCC, providing new insights for the clinical management of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71460","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:54:58Z","timestamp":1767203698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mechanistic Insights and Therapeutic Potential of Small Nucleolar\n                    <scp>RNA<\/scp>\n                    Host Genes in the Carcinogenesis of Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiajia","family":"Luo","sequence":"first","affiliation":[{"name":"School of Pharmacy Youjiang Medical University for Nationalities  Baise Guangxi P. R. China"},{"name":"School of Basic Medical Sciences Youjiang Medical University for Nationalities  Baise Guangxi P. R. 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