{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:35:13Z","timestamp":1766748913283,"version":"3.48.0"},"reference-count":36,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The prognostic value of radiomic quantitative features measured on pretreatment\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT was investigated in patients with advanced\u2010stage Hodgkin lymphoma (HL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective study of 176 HL patients diagnosed between 2006 and 2017. A dozen of PET\/CT\u2010derived features were extracted via\n                      <jats:italic>Oncometer3D<\/jats:italic>\n                      from baseline\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT images. The receiver operating characteristic (ROC) curves, Kaplan\u2013Meier method, and Cox analyses were used to assess the prognostic factors for Overall Survival (OS) and Progression\u2010Free Survival (PFS) censored at 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four different clusters were identified among the 12 PET parameters analyzed: activity, tumor burden, fragmentation\u2010massiveness, and dispersion. On ROC analyses, medEdgeD, a massiveness parameter, had the highest AUC for OS (0.72) and PFS (0.6). Patients with high baseline medEdgeD had a significantly worse PFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) in both Kaplan\u2013Meier and Cox univariate analyses. Furthermore, medEdgeD remained statistically significant in a multivariate analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008 for OS and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014 for PFS) including various TEP and clinical parameters used in daily routine. In addition, in sub\u2010group analyses, a significantly worse prognosis was observed for patients with ABVD and with high baseline medEdgeD value (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0082 for OS and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001 for PFS). Moreover, in the bulky subgroup, medEdgeD improved prognostic accuracy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PET parameters describing massiveness, in particular medEdgeD, are significantly correlated with prognosis in HL patients for OS and PFS, especially when treated with ABVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71462","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:20:50Z","timestamp":1765632050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Massiveness Parameters Measured on Baseline FDG PET in Advanced\u2010Stage Hodgkin Lymphoma"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3548-9461","authenticated-orcid":false,"given":"S.","family":"Draye\u2010Carbonnier","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010D.","family":"Mihailescu","sequence":"additional","affiliation":[{"name":"Department of Statistics and Clinical Research Unit Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pinochet","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Texte","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stamatoullas\u2010Bastard","sequence":"additional","affiliation":[{"name":"Department of Hematology Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"},{"name":"QuantIF\u2010LITIS (EA 4108\u2010FR CNRS 3638), Faculty of Medicine University of Rouen  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"},{"name":"QuantIF\u2010LITIS (EA 4108\u2010FR CNRS 3638), Faculty of Medicine University of Rouen  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Decazes","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Centre Henri Becquerel  Rouen France"},{"name":"QuantIF\u2010LITIS (EA 4108\u2010FR CNRS 3638), Faculty of Medicine University of Rouen  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy080"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.4803"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26717"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30784-8"},{"key":"e_1_2_10_8_1","first-page":"S1","article-title":"Mexican Consensus on Hodgkin's Lymphoma","volume":"157","author":"\u00c1lvarez\u2010Vera J. 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