{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:45:05Z","timestamp":1791229505271,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102022\u201000009"],"award-info":[{"award-number":["226\u20102022\u201000009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102024\u201000176"],"award-info":[{"award-number":["226\u20102024\u201000176"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) with synchronous peritoneal metastasis (SPM) presents poor prognosis and complex treatment challenges. This study aimed to identify independent prognostic factors and develop nomogram\u2010based prediction models for overall survival (OS) and progression\u2010free survival (PFS) in CRC patients with SPM (CRC\u2010SPM) undergoing cytoreductive surgery (CRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 218 CRC\u2010SPM treated with CRS between October 2010 and April 2022. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors for OS and PFS. Nomogram models were constructed based on these factors, and their predictive accuracy was assessed using calibration curves, ROC curves, and Decision Curve Analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For OS, independent factors included age &gt;\u200965\u2009years (HR\u2009=\u20092.464,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), N2 stage (HR\u2009=\u20092.720,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), &gt;\u200913 lymph nodes resected (HR\u2009=\u20090.496,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), and postoperative chemotherapy (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20090.300,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). For PFS, independent factors were age &gt;\u200965\u2009years (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20091.578,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), concurrent liver metastasis (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20091.664,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), &gt;\u200914\n                      <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\n                      score (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20091.630,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), and presence of ascites (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20091.706,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Nomogram models for predicting OS and PFS had AUC values of 0.717, 0.759, and 0.773 for OS, and 0.659, 0.689, and 0.790 for PFS at 1, 2, and 3\u2009years, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identified key prognostic factors and developed reliable nomogram models for predicting OS and PFS in CRC\u2010SPM. The findings highlight the importance of postoperative chemotherapy and intraoperative lymph node dissection and suggest focusing on high\u2010risk factors such as age and N2 stage in clinical practice. The nomogram models provide a valuable tool for personalized prognosis assessment and treatment planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71464","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T16:20:58Z","timestamp":1766766058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Factors and Nomogram\u2010Based Prediction Models for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis Undergoing Cytoreductive Surgery: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-9057","authenticated-orcid":false,"given":"Xiaoxu","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 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Innovation in Digestive System Tumors, Ministry of Education Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-3717","authenticated-orcid":false,"given":"Kefeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National 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