{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:52:16Z","timestamp":1784753536616,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0567"],"award-info":[{"award-number":["2025ZNSFSC0567"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Activating colony\u2010stimulating factor 3 receptor (\n CSF3R<\/jats:italic>\n ) mutations are uncommon in acute myeloid leukemia (AML), and their prognostic significance remains unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We compared clinical, treatment response, and survival data between\n CSF3R<\/jats:italic>\n \u2010mutated and\n CSF3R<\/jats:italic>\n \u2010wild\u2010type AML patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CSF3R<\/jats:italic>\n \u2010mutated cases presented a distinct molecular profile, with T618I and T640A being the most frequent variants. Common molecular aberrations included\n CEBPA bZip<\/jats:italic>\n mutations (40%) and CBF fusions (23%), as well as secondary\u2010type AML\u2010associated mutations such as those in\n ASXL1<\/jats:italic>\n ,\n SRSF2<\/jats:italic>\n , and\n EZH2<\/jats:italic>\n . In contrast,\n NPM1<\/jats:italic>\n mutations were significantly less common in\n CSF3R<\/jats:italic>\n \u2010mutated patients (\n p<\/jats:italic>\n \u2009=\u20090.03). Induction responses were poorer in\n CSF3R<\/jats:italic>\n \u2010mutated AML patients, with lower complete remission (55.6% vs. 78.8%,\n p<\/jats:italic>\n \u2009=\u20090.004), reduced measurable residual disease (MRD) negativity (53.3% vs. 87.6%,\n p<\/jats:italic>\n \u2009<\u20090.001), and shorter MRD maintenance duration (5.4 vs. 21.6\u2009months,\n p<\/jats:italic>\n \u2009<\u20090.001). According to the logistic regression analysis,\n CSF3R<\/jats:italic>\n mutation emerged as an independent predictor of induction failure (\n p<\/jats:italic>\n \u2009<\u20090.001). Survival outcomes were also inferior: the median overall survival (OS) was 20.7\u2009months versus not reached (\n p<\/jats:italic>\n \u2009=\u20090.0013), and progression\u2010free survival was 9.4 versus 63.6\u2009months (\n p<\/jats:italic>\n \u2009<\u20090.0001). The adverse impact of\n CSF3R<\/jats:italic>\n mutations was most pronounced in\n CEBPA<\/jats:italic>\n bZip AML.\n CSF3R<\/jats:italic>\n mutations abrogated the expected favorable prognosis (3\u2010year OS: 44.2% vs. 88.2%,\n p<\/jats:italic>\n \u2009=\u20090.0008). Conversely,\n CSF3R<\/jats:italic>\n status did not affect outcomes in CBF\u2010rearranged patients (\n p<\/jats:italic>\n \u2009=\u20090.70).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CSF3R<\/jats:italic>\n mutations define a distinct, high\u2010risk AML subset characterized by an inferior treatment response and survival, warranting incorporation into future risk stratification.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.71471","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T03:36:04Z","timestamp":1766374564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CSF3R<\/i>\n Mutations Imply Adverse Prognostic Impact in Adult Acute Myeloid Leukemia Patients: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-8796","authenticated-orcid":false,"given":"Jinjun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-9711","authenticated-orcid":false,"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-4078","authenticated-orcid":false,"given":"Hongbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital, Sichuan University Chengdu P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00108-3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-234120"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214514"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31586"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004179"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03699-7"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13762"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.11.013"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009652"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.32"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6669"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.10.002"},{"issue":"3","key":"e_1_2_13_15_1","first-page":"177","article-title":"Chinese Guidelines for Diagnosis and Treatment of Adult Acute Myeloid Leukemia (Not APL) (2017)","volume":"38","author":"Leukemia & Lymphoma Group, Chinese Society of Hematology, Chinese Medical Association","year":"2017","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"9","key":"e_1_2_13_16_1","first-page":"705","article-title":"Chinese Guidelines for Diagnosis and Treatment of Adult Acute Myeloid Leukemia (Not APL) (2023)","volume":"44","author":"Leukemia & Lymphoma Group, Chinese Society of Hematology, Chinese Medical Association","year":"2023","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918307117"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.06.032"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.04.006"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27643"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-705053"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29336-y"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.508440"},{"issue":"3","key":"e_1_2_13_24_1","first-page":"946","article-title":"Csf3r Mutations in Mice Confer a Strong Clonal HSC Advantage via Activation of Stat5","volume":"118","author":"Liu F.","year":"2008","journal-title":"Journal of Clinical Investigation"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00895"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-130196"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:26:12Z","timestamp":1766748372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":25,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cam4.71471"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71471","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71471"}}