{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:09:29Z","timestamp":1784005769105,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The tumor control rate after stereotactic radiosurgery (SRS) for neurofibromatosis type 2\u2010associated vestibular schwannomas (NF2\u2010VSs) compared to sporadic vestibular schwannomas (S\u2010VSs) remains unclear. This nationwide, multicenter, retrospective study (KGKRS\u201021\u2010001) aimed to clarify this issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 4718 patients treated with SRS for vestibular schwannomas were analyzed from 13 nationwide institutions in Korea. NF2\u2010VS cases were propensity score\u2010matched with S\u2010VS cases at a ratio of 1:1, based on age, tumor volume, and marginal dose, resulting in 122 cases in each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences in age, tumor volume, or marginal dose were observed between the matched cohorts. The overall tumor control rates at 1, 3, and 10\u2009years after SRS were 93.3%, 87.7%, and 80.7%, respectively, with no significant difference between NF2\u2010VS and S\u2010VS groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63). Subgroup analysis showed that age \u2264\u200919\u2009years was a significant negative prognostic factor for tumor control in NF2\u2010VS patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas no such correlation was found in the S\u2010VS cohort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SRS provides comparable tumor control for NF2\u2010VSs and S\u2010VSs. However, among NF2\u2010VS patients, younger age (\u2264\u200919\u2009years) was associated with poorer tumor control, suggesting that age may be a critical factor in treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71480","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T04:44:40Z","timestamp":1766810680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tumor Control After Radiosurgery in Sporadic and Neurofibromatosis Type 2 Vestibular Schwannomas"],"prefix":"10.1002","volume":"15","author":[{"given":"So Young","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Seoul National University Bundang Hospital  Seongnam\u2010si South 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Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Korea University Guro Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Won","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Korea University Guro Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Hyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyungpook National University Hospital, Kyungpook National University School of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyungpook National University Hospital, Kyungpook National University School of Medicine  Daegu South 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