{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:30:48Z","timestamp":1772987448861,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["28893"],"award-info":[{"award-number":["28893"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In Italy, cure indicators of cutaneous malignant melanoma according to Breslow tumour thickness have never been assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the time trend in 1\u2010year net survival (NS), 5|1\u2010year conditional NS (CNS) and cure fraction (CF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 10 cancer registries and 13,377 patients aged 15\u201374\u2009years were used. Five|1\u2010year CNS was defined as the probability of surviving 5\u2009years given that the patient has survived 1\u2009year. CF was defined as the proportion of patients with the same life expectancy as the general population. One\u2010year NS and 5|1\u2010year CNS were contrasted between 2013\u20132017 and 2003\u20132007, and CF between 2015 and 2005.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For lesions up to 4\u2009mm thick, 1\u2010year NS reached a level\u2009&gt;\u200998.0%. In 2013\u20132017, 5|1\u2010year CNS was above 90% for men and women with lesions up to 2.0\u2009mm thick and increased markedly for men with lesions &gt;\u20092.0\u20134.0\u2009mm thick (65.1% to 82.4%) and &gt;\u20094.0\u2009mm thick (57.6% to 69.4%). The CF of patients with a melanoma \u2264\u20091.0\u2009mm thick was approximately 100% in both sexes, and nearly doubled from 2005 to 2015 (28% to 54%) for men aged 55\u201374\u2009years with a melanoma &gt;\u20094.0\u2009mm thick.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with a melanoma \u2264\u20091\u2009mm thick have the same life expectancy as the general population. The increase in the CF of men with thick lesions supports the hypothesis that novel therapies, approved in Italy since 2013, offer the possibility of cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71486","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:43:41Z","timestamp":1768016621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trends in Survival and Cure Indicators of Thin and Thick Cutaneous Malignant Melanoma in Italy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-3347","authenticated-orcid":false,"given":"Silvia","family":"Mancini","sequence":"first","affiliation":[{"name":"Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori  Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-0745","authenticated-orcid":false,"given":"Federica","family":"Toffolutti","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-6656","authenticated-orcid":false,"given":"Federica","family":"Zamagni","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori  Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-8119","authenticated-orcid":false,"given":"Lauro","family":"Bucchi","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori  Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-2034","authenticated-orcid":false,"given":"Emanuele","family":"Crocetti","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori  Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-3479","authenticated-orcid":false,"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bella","sequence":"additional","affiliation":[{"name":"Siracusa Cancer Registry, Provincial Health Authority of Siracusa  Siracusa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Registro Tumori Integrato CT\u2010ME\u2010EN, Policlinico G. 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