{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:46:51Z","timestamp":1788184011802,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007232","name":"Radiumhemmets Forskningsfonder","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007363","name":"Stiftelsen Acta Oto-Laryngologica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with T3 laryngeal squamous cell carcinoma (LSCC) face a high risk of local recurrence after chemoradiotherapy (CRT) or radiotherapy (RT). This study examines whether tumor volume and inner cortex cartilage invasion (ICCI) predict local recurrence and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Eighty\u2010six patients with T3 LSCC, treated with RT or CRT at the Karolinska University Hospital between 2005 and 2021, were included. Cox regression assessed the effect of associations between tumor volume and ICCI on local failure and 5\u2010year mortality, adjusting for treatment modality, tumor subsite, and vocal cord mobility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High tumor volume (&gt;\u20095\u2009mL) was associated with a threefold increase in local failure risk (HR 3.11, 95% CI 1.47\u20136.55). No significant associations were found between tumor volume and mortality, ICCI and local failure, or ICCI and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results demonstrate that a larger tumor volume correlates with a reduced treatment response for patients with T3 LSCC treated with RT or CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71500","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:17:57Z","timestamp":1766819877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting Local Recurrence in\n                    <scp>T3<\/scp>\n                    Laryngeal Squamous Cell Carcinoma: An Analysis of Tumor Volume and Cartilage Invasion Prior to Radiotherapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-1694","authenticated-orcid":false,"given":"Rasmus","family":"Blomkvist","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"},{"name":"Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Palmgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"},{"name":"Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eivind","family":"Gottlieb\u2010Vedi","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Jonmarker","family":"Jaraj","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Marklund","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"},{"name":"Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Surgical Sciences, Section of Otolaryngology and Head and Neck Surgery Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalle","family":"Hammarstedt\u2010Nordenvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology Karolinska Institutet, and Karolinska University Hospital  Stockholm Sweden"},{"name":"Medical Unit, Head Neck, Lung and Skin Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32292"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06780-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28227"},{"issue":"8","key":"e_1_2_10_6_1","article-title":"Survival Outcomes in T3 Laryngeal Cancers: Primary Total Laryngectomy vs. Concurrent Chemoradiation or Radiation Therapy\u2014A Meta\u2010Analysis","volume":"11","author":"Rao K. 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