{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:36:38Z","timestamp":1784655398026,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019173","name":"Roland Ernst Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Young adults (18\u201345\u2009years) with head\u2010and\u2010neck cancer represent a unique population with limited data on quality of life (QoL) and return\u2010to\u2010work after radiotherapy. This bicentric study aimed to evaluate these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Conducted at two comprehensive cancer centers, the study included young head\u2010and\u2010neck cancer survivors treated with curative radiotherapy between 2003 and 2023. QoL was assessed with EORTC QLQ\u2010C30 and HN43; distress, depression, and anxiety with the NCCN Distress Thermometer, PHQ\u20109, and GAD\u20107; fear of cancer progression and work ability with FoP\u2010Q\u2010SF and WAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 83 eligible patients, 58 (70%) participated. The median age at radiotherapy was 41\u2009years, with a balanced gender distribution (40% female, 60% male). The median time from radiotherapy to questionnaire completion was 82.5\u2009months. Mean global QoL was 65.0, comparable to the age\u2010 and gender\u2010matched reference population (67.2). Clinically relevant distress was reported by 52%, severe depressive symptoms by 12%, moderate\u2010to\u2010severe anxiety by 21%, and strong fear of cancer progression by 38%. At the time of the study, 66% had returned to work. Those who returned to work reported lower symptom scores, and less depression, anxiety, and distress. In the multiple regression analysis, gender was significantly associated with return to work, with females showing higher odds of returning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While overall QoL was comparable to the general population, young head\u2010and\u2010neck cancer survivors face psychological and work reintegration challenges. Returning to work is associated with improved QoL and reduced psychological symptoms, highlighting the need for tailored survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71502","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:50:52Z","timestamp":1766998252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quality of Life and Return to Work After Radiotherapy in Young Adults With Head\u2010and\u2010Neck Cancer\u2014A Bicentric Cross\u2010Sectional Observational Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Charlotte","family":"Pannenbecker","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Medical Center Leipzig  Leipzig Germany"},{"name":"Comprehensive Cancer Center Central (CCCG) Germany, Partner Site Leipzig  Leipzig 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