{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:03Z","timestamp":1786706823390,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Integration of locoregional treatments (LRTs) with atezolizumab plus bevacizumab (atezo\/bev) has improved treatment outcomes, enabling an increasing number of patients with unresectable hepatocellular carcinoma (HCC) to achieve a complete response (CR). A comprehensive analysis of recurrence following CR may provide insights into prognosis. This study aimed to identify the factors associated with post\u2010CR recurrence in unresectable HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 15 patients with unresectable HCC who achieved CR with atezo\/bev therapy. The incidence and characteristics of post\u2010CR recurrence were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten patients achieved CR by combining LRT with atezo\/bev, whereas five achieved CR with atezo\/bev alone. The post\u2010CR recurrence rate was 53.3% (recurrence group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098; non\u2010recurrence group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097). No significant differences were observed between the recurrence and non\u2010recurrence groups in HCC treatment history prior to atezo\/bev initiation, predictive factors for treatment response, including the neutrophil\u2010to\u2010lymphocyte ratio, hepatic functional reserve, and tumor burden at the initiation of atezo\/bev, treatment progress, or frequency of atezo\/bev maintenance therapy post\u2010CR. In multivariate analysis, a history of \u2265\u20092 HCC treatments prior to atezo\/bev initiation was independently associated with post\u2010CR recurrence (hazard ratio, 6.744; 95% confidence interval, 1.189\u201338.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031); conversely, predictive factors for atezo\/bev response, treatment progress, and maintenance therapy did not contribute to post\u2010CR recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the high post\u2010CR recurrence rate with atezo\/bev in unresectable HCC, vigilant surveillance remains essential even after achieving CR, particularly in patients with \u2265\u20092 prior HCC treatments before atezo\/bev initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71552","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:12:44Z","timestamp":1769494364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Prior Treatment History on Recurrence After Complete Response to Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-850X","authenticated-orcid":false,"given":"Tasuku","family":"Nakabori","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka 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Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-8091","authenticated-orcid":false,"given":"Ryoji","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-8960","authenticated-orcid":false,"given":"Kenji","family":"Ikezawa","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka 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