{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:08Z","timestamp":1786706828032,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["1124002"],"award-info":[{"award-number":["1124002"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite favourable survival prognosis, the main concern for ductal carcinoma in\u00a0situ (DCIS) is local recurrence, especially progression to invasive cancer. This study identified factors associated with breast events following DCIS treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women with unilateral DCIS between 2000 and 2022 were identified from New Zealand Breast Cancer Foundation National Register. The primary endpoint was cumulative incidence of invasive breast cancer, ipsilateral (iIBC) or contralateral (iCBC). Secondary endpoints included ipsilateral breast event (IBE), in\u00a0situ or invasive, and any breast event (IBE or CBC). Fine\u2010Gray models were used to identify the associated factors and estimate subdistribution hazard ratios (sHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 5740 patients followed for a median duration of 4.8\u2009years, the 5\u2010 and 10\u2010year cumulative risks were 3.0% (95% CI, 2.4%, 3.5%) and 6.6% (95% CI, 5.7%, 7.6%) for iIBC, and 2.7% (95% CI, 2.2%, 3.3%) and 6.3% (95% CI, 5.4%, 7.3%) for iCBC, respectively. A higher risk of iIBC was observed in women aged under 45 at diagnosis (sHR, 1.81; 95% CI: 1.18, 2.79) or had DCIS size &gt;\u200920\u2009mm (sHR, 1.42; 1.05, 1.93), and a lower risk in those who received additional RT after BCS (HR: 0.61; 0.44, 0.84) or mastectomy (sHR, 0.21; 0.13, 0.32). Similar associations were observed for IBE and any breast event, for which surgical margin &lt;\u20092\u2009mm was also associated with a higher risk. Having surgery at a private facility, where higher\u2010risk patients were likely to be treated, was associated with a higher risk of iCBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCIS size, surgical approach, and age at diagnosis influenced the risk of breast events after DCIS, which may be considered in efforts to improve treatment strategies for higher\u2010risk women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71558","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:04:21Z","timestamp":1769681061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Breast Events After Treatment of Ductal Carcinoma In\u00a0Situ in Women: A Population\u2010Based Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4409-9516","authenticated-orcid":false,"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Elwood","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Cavadino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9356-9965","authenticated-orcid":false,"given":"Phyu Sin","family":"Aye","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandar","family":"Tin Tin","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206809"},{"key":"e_1_2_11_3_1","volume-title":"Management of Early Breast Cancer","author":"New Zealand Guidelines Group","year":"2009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1570"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075498"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgq039"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgq040"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.8847"},{"key":"e_1_2_11_10_1","unstructured":"Ministry of Health \u201cAbout BreastScreen Aotearoa. 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