{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:26:37Z","timestamp":1786706797221,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Metaplastic breast cancer (metBC) is a rare subtype of breast cancer known for its challenging management. The impact of this histological subtype on prognosis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from the Swedish Cancer Registry between 2008 and 2018. Patients with metBC were matched 2:1 with breast cancer cases of no special type (NST). Survival outcomes were analyzed using cause\u2010specific hazard models for breast cancer specific survival (BCSS) and Cox proportional\u2010hazards models for overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 127 metBC patients were matched 2:1 with 245 NST patients, with a median follow\u2010up period of 54\u2009months. When adjusted for matching variables and treatment\u2010related characteristics, metBC was not significantly associated with either BCSS (cause\u2010specific Hazard Ratio (HR): 1.13; 95% Confidence Interval (CI): 0.66\u20131.92) or OS (HR: 1.23; 95% CI: 0.83\u20131.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With appropriate treatment, metBC may have survival outcomes comparable to NST. Larger studies with longer follow\u2010up are needed to provide further insights.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71570","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:19:01Z","timestamp":1769595541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis of Metaplastic Breast Cancer: A Population\u2010Based Matched Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-3752","authenticated-orcid":false,"given":"Marie","family":"Bergman","sequence":"first","affiliation":[{"name":"Department of Oncology Central Hospital  Karlstad Sweden"},{"name":"Institution for Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Schiza","sequence":"additional","affiliation":[{"name":"Department of Oncology Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Boyaci","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Cancer Diagnostics Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Acs","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Cancer Diagnostics Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Matikas","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Pathology, Karolinska Institute, and Breast Center Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Cancer Diagnostics Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-0194","authenticated-orcid":false,"given":"Antonis","family":"Valachis","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Health \u00d6rebro University Hospital, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial 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