{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:26:36Z","timestamp":1786706796060,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008816","name":"University of Sri Jayewardenepura","doi-asserted-by":"publisher","award":["ASP\/01\/RE\/AHS\/2022\/91"],"award-info":[{"award-number":["ASP\/01\/RE\/AHS\/2022\/91"]}],"id":[{"id":"10.13039\/501100008816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metformin, the common anti\u2010hyperglycemic agent, is emerging with pharmacological significance as an effective anti\u2010cancer modulator. Its efficacy as an anti\u2010cancer modulator is reported in pre\u2010clinical and clinical studies. Therefore, an attempt was made to identify the possible in\u00a0vitro anti\u2010cancer molecular mechanisms studied on breast cancer (BC) cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An advanced literature search was conducted in the PubMed database using search terms \u201cMetformin, Cell culture, Breast neoplasms.\u201d Different anti\u2010cancer molecular mechanisms induced by metformin (MET) identified in cell culture studies are presented in this paper.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>It was identified that MET induces molecular pathways that exert anti\u2010cancer effects when treated on BC cells. Inhibition of oxidative phosphorylation, adenosine monophosphate\u2010activated protein kinase mediated anticancer effects, anti\u2010proliferation and inhibition of cell migration, alteration of tumor micro\u2010environment, synergetic effects with conventional chemotherapies and other potential molecules, induced apoptosis and ferroptosis were mainly identified as MET\u2010induced pathways that affect BC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metformin induces diverse anti\u2010cancer biochemical pathways through which it exhibits a potential to be used as an anti\u2010cancer therapeutic in BC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71573","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:18:56Z","timestamp":1769595536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metformin\u2010Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-1194","authenticated-orcid":false,"given":"Ambulugala Gamage Rajika Greshamali","family":"Jinadasa","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Faculty of Allied Health Sciences University of Sri Jayewardenepura  Nugegoda Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-4917","authenticated-orcid":false,"given":"N. 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