{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:15Z","timestamp":1786706835642,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH\u201010707015"],"award-info":[{"award-number":["NCKUH\u201010707015"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Radiofrequency ablation (RFA) is a standard treatment for patients with early\u2010stage hepatocellular carcinoma (HCC). However, analgesics are often insufficient in mitigating post\u2010RFA pain. The lidocaine patch is being investigated as an alternative for acute pain relief, though it has not yet been used for post\u2010RFA pain. This study aims to evaluate the effect of lidocaine patches on post\u2010RFA pain for patients with HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing RFA treatment were randomly assigned to an intervention group, receiving lidocaine patches (LP group), or a control group, receiving placebo patches (PP group). The primary endpoint was the Visual Analog Scale (VAS) pain score. The secondary endpoint was rescue analgesic use, quantified as the equivalent cumulative dose of residual morphine. Both were assessed concurrently every 4\u2009h on the first day post\u2010RFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 86 patients in the LP group and 68 patients in the PP group completed the study. Pain scores did not differ between the two groups at any time point. However, the equivalent cumulative dose of residual morphine was lower in the LP group compared to the PP group, with statistically significant differences at time points T4\u2013T6 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032, respectively). After adjusting for confounding factors, multiple linear regression analysis yielded similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VAS pain scores, the primary endpoint, were not significantly different between the two groups. However, the objective equivalent cumulative dose of residual morphine was significantly reduced, implying that the lidocaine patch lowered residual systemic opioid exposure. We conclude that the lidocaine patch may be useful to reduce opioid use post\u2010RFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT05732181<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71581","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T01:23:41Z","timestamp":1771205021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Lidocaine Patches on Post\u2010Radiofrequency Ablation Pain in Patients With Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-1921","authenticated-orcid":false,"given":"Chen\u2010Ju","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nursing National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-3097","authenticated-orcid":false,"given":"Wei\u2010Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"School of Nursing, College of Nursing Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Biostatistics Consulting Center National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Cheng","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ju","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Institute of Allied Health Sciences College of Medicine, National Cheng Kung University  Tainan 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