{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:35:43Z","timestamp":1789734943097,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mature B\u2010cell neoplasms chronic lymphocytic leukaemia\/small lymphocytic lymphoma (CLL\/SLL) and waldenstr\u00f6m macroglobulinaemia (WM) are highly prevalent in older populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study quantified the incidence, prevalence and relative survival\/mortality rate in Australia for CLL\/SS and WM and reported the past trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Methods<\/jats:title>\n                    <jats:p>All CLL\/SLL and WM cases registered from January 2009 to December 2018 in Victoria, Tasmania, Australian Capital Territory and Queensland were identified. Incidence rates over the observed period (2009\u20132018) were calculated and then projected to 2038 using linear regression. Kaplan\u2013Meier (KM) curves were used to estimate survival rates from 2009 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2009 and 2018, the annual age\u2010standardised incidence rates of CLL\/SLL (range, 600.05\u2013887.92 cases per 10\n                      <jats:sup>7<\/jats:sup>\n                      person\u2010years) and WM (range, 41.48\u201378.19 cases per 10\n                      <jats:sup>7<\/jats:sup>\n                      person\u2010years) showed an increasing trend (coefficient: 26.98 [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023] and 3.20 [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009], respectively). A similar trend was seen in age\u2010standardised prevalence proportions by sex and age group. KM curves showed 10\u2010year survival rates of 53% (CLL\/SLL) and 42% (WM) at the end of the available data period (2018). Differences in survival between sexes were not statistically significant in the log\u2010rank test, but univariable analysis showed male sex and older age were associated with a higher risk of mortality in both condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The change in survival over time may reflect disease characteristics and recent advances in treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the increasing incidence and relatively high survival of CLL\/SLL and WM, strategic planning for the future management is warranted in the context of Australia\u2019s ageing population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71582","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:55:39Z","timestamp":1769993739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence, Prevalence, Survival and Mortality of Chronic Lymphocytic Leukaemia\/Small Lymphocytic Lymphoma and Waldenstr\u00f6m Macroglobulinaemia in Australia"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0134-4510","authenticated-orcid":false,"given":"Dieu","family":"Nguyen","sequence":"first","affiliation":[{"name":"Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalika Bohingamu","family":"Mudiyanselage","sequence":"additional","affiliation":[{"name":"Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Talaulikar","sequence":"additional","affiliation":[{"name":"Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-5595","authenticated-orcid":false,"given":"Fei\u2010Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"BeOne Medicines Ltd.  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxiong","family":"Tang","sequence":"additional","affiliation":[{"name":"BeOne Medicines Ltd.  San Carlos California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Kamal","sequence":"additional","affiliation":[{"name":"Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-1140","authenticated-orcid":false,"given":"Lan","family":"Gao","sequence":"additional","affiliation":[{"name":"Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2021.20463"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.849"},{"issue":"7","key":"e_1_2_12_5_1","first-page":"493","article-title":"Chronic Lymphocytic Leukaemia: An Updated Approach to Diagnosis and Management in General Practice","volume":"46","author":"Tomlinson R.","year":"2017","journal-title":"Australian Family Physician"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15980"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18036"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy146"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16207"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00916-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012221"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.21.00380"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0257-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.657016"},{"key":"e_1_2_12_15_1","unstructured":"Australian Institute for Health and Welfare \u201cCancer Data in Australia: Blood Cancer Incidence and Survival by Histology (Experimental Data) \u201d2024 https:\/\/www.aihw.gov.au\/reports\/cancer\/cancer\u2010data\u2010in\u2010australia\/contents\/blood\u2010cancer\u2010incidence\u2010and\u2010survival\u2010by\u2010histology\u2010e."},{"key":"e_1_2_12_16_1","unstructured":"Australian Institute for Health and Welfare \u201cCancer Data in Australia: Cancer Summary Data Visualisation \u201d2024 https:\/\/www.aihw.gov.au\/reports\/cancer\/cancer\u2010data\u2010in\u2010australia\/contents\/cancer\u2010rankings\u2010data\u2010visualisation."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28849"},{"key":"e_1_2_12_18_1","unstructured":"Australian Institute of Health and Welfare \u201cCancer Data in Australia \u201d2024 https:\/\/www.aihw.gov.au\/reports\/cancer\/cancer\u2010data\u2010in\u2010australia\/contents\/technical\u2010notes\/methods."},{"key":"e_1_2_12_19_1","unstructured":"National Cancer Institute: Statistical Methodology and Applications Branch \u201cSurveillance Research Program: Joinpoint Regression Program \u201dversion 5.3.0.0 2024 https:\/\/surveillance.cancer.gov\/help\/joinpoint\/."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu024"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1680840"},{"key":"e_1_2_12_22_1","unstructured":"Australian Institute for Health and Welfare \u201cPrinciples on the Use of Direct Age\u2010Standardisation in Administrative Data Collections: For Measuring the Gap Between Indigenous and Non\u2010Indigenous Australians \u201d2011 https:\/\/www.aihw.gov.au\/reports\/indigenous\u2010australians\/principles\u2010on\u2010the\u2010use\u2010of\u2010direct\u2010age\u2010standardisatio\/summary."},{"issue":"4","key":"e_1_2_12_23_1","first-page":"1478","article-title":"A Generic Model for the Assessment of Disease Epidemiology: The Computational Basis of DisMod II","volume":"1","author":"Barendregt J. 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