{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:09Z","timestamp":1786706829135,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972164"],"award-info":[{"award-number":["81972164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Crizotinib is the classic first\u2010line treatment for\n                      <jats:italic>ROS<\/jats:italic>\n                      1\u2010rearranged NSCLC. However, data on the clinical progression modes and recommended options for subsequent treatments after crizotinib treatment failure are limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight patients were categorized into dramatic or gradual\/local progression groups. We analyzed the clinical characteristics, survival outcomes, and potential resistance mechanisms in different progression modes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median progression\u2010free survival (mPFS) in the dramatic and gradual\/local progression groups was 8.0 and 22.0\u2009months, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The median overall survival (mOS) was 14.2 and 90.3\u2009months in the dramatic progression and gradual\/local progression groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among patients with dramatic progression after crizotinib failure, significant differences were shown in median post\u2010progression overall survival (mpOS) (7.1 vs. 3.6 vs. 1.0\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) and mOS (23.1 vs. 18.3 vs. 10.6\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) across subsequent chemotherapy, targeted therapy, or best supportive care (BSC).\n                      <jats:italic>ROS<\/jats:italic>\n                      1 kinase domain point mutations were detected predominantly in the dramatic progression group, while the activation of bypass and downstream pathways occurred in the gradual\/local progression group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The progression modes of\n                      <jats:italic>ROS<\/jats:italic>\n                      1 rearrangement may predict survival benefits and provide subsequent treatment strategies in\n                      <jats:italic>ROS<\/jats:italic>\n                      1\u2010rearranged NSCLC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71592","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T23:49:53Z","timestamp":1770248993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Progression Modes of Crizotinib Failure and Subsequent Management of Advanced Non\u2010Small Cell Lung Cancer With\n                    <i>ROS<\/i>\n                    1 Rearrangement"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7117-1295","authenticated-orcid":false,"given":"Quan\u2010Quan","family":"Tan","sequence":"first","affiliation":[{"name":"Guangdong Lung Cancer Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qing","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Medical University Cancer Institute &amp; Hospital National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Er","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology The Fifth Affiliated Hospital, Southern Medical University  Guangzhou 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