{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:06Z","timestamp":1786706826903,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Progression of hepatocellular carcinoma (HCC) and cardiovascular thrombosis (CVT) has a bidirectional causal relationship. CVT complications will increase in patients with HCC due to etiology shift from viral hepatitis to metabolic dysfunction\u2010related steatohepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the clinical impact of CVT, focusing on patients with HCC treated after transarterial chemoembolization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study enrolled 402 patients including 79 patients with CVT in a single university hospital. Cox proportional hazard model analysis was performed to identify independent prognostic factors. After adjusting for baseline characteristics by propensity score matching, the survival impact of the CVT complication was evaluated using the Kaplan\u2013Meier curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A multivariate analysis determined that CVT complication was an independent risk factor for overall deaths in patients with HCC (HR\u2009=\u20091.751, IQR 1.203\u20132.548,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Propensity score matching generated a pair of 54\u2010patient cohorts. The median survival time of patients with CVT (1106\u2009days) shortened to half compared to those without CVT (2707\u2009days, HR\u2009=\u20092.298, IQR: 1.399\u20134.169,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0020). While recurrence\u2010free survival was not significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), post\u2010recurrence survival was shorter in patients with CVT (2150\u2009days vs. 1008\u2009days, HR\u2009=\u20091.945, IQR: 1.150\u20133.740,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0188).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Assuming that the expected life expectancy is only half that of uncomplicated cases of CVT, CVT might be a major prognostic factor in patients with HCC, following tumor burden and functional hepatic reserve.<\/jats:p>\n                  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