{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:16:11Z","timestamp":1792120571251,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8247153912"],"award-info":[{"award-number":["8247153912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010Hodgkin lymphoma (NHL) is increasingly prevalent in middle\u2010aged and elderly populations, contributing to the rising global health burden, particularly in high\u2010income countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis utilized data from the Global Burden of Disease (GBD) study (1990\u20132021) to examine temporal trends in age\u2010standardized incidence, mortality, and disability\u2010adjusted life year (DALY) rates of NHL among middle\u2010aged and older adult populations, incorporating age\u2010 and sex\u2010stratified comparisons. Furthermore, projections for the subsequent 30\u2009years were generated using Bayesian age\u2010period\u2010cohort (BAPC) modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1990 to 2021, the number of cases, deaths, and DALYs in middle\u2010aged and older people with NHL had significant increases. Age\u2010standardized incidence rates exhibited an increasing trend (estimated annual percentage change [EAPC]\u2009=\u20090.53), whereas mortality (EAPC\u2009=\u2009\u22120.33) and DALY rates (EAPC\u2009=\u2009\u22120.52) demonstrated a decreasing trend. The Western European region and high SDI countries are the core burden areas for middle\u2010aged and elderly populations with NHL globally. Lower\u2010middle SDI countries experienced the fastest increase in mortality (EAPC\u2009=\u20090.38) and DALY rates (EAPC\u2009=\u20090.22), while high\u2010SDI countries experienced the steepest decline in all metrics. The DALY burden showed its peak value at 65\u201369\u2009years among middle\u2010aged and aged adults with NHL, while the morbidity and mortality burden reached their highest point at 70\u201374\u2009years. When stratified by gender, the overall burden was higher in males than in females. High BMI causes the burden of NHL DALY to rise with increasing SDI, up to 39.14% in High\u2010income North America. By 2050, global NHL incidence is projected to increase modestly by 0.28%, whereas mortality and DALY burdens are expected to decline markedly by 30.67% and 23.02%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NHL in middle\u2010aged and older adults represents a significant global public health burden, necessitating context\u2010specific interventions due to variations across regions, genders, and age groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71609","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:51:41Z","timestamp":1773222701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Burden of Middle\u2010Aged and Elderly Patients With Non\u2010Hodgkin Lymphoma From 1990 to 2021: A Systematic Analysis Based on the Global 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