{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:26:40Z","timestamp":1786706800116,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the absence of randomized trials, selecting second or later\u2010line therapies in advanced sarcoma generally hinges on histology, patient performance status, and toxicity profile. We herein report a real\u2010world sarcoma referral center experience on continuous infusion Ifosfamide (ciIFO), in advanced Soft tissue sarcomas (STS) and bone sarcomas (BS) patients, assessing both efficacy and toxicity profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively collected data of STS and BS patients treated with ciIFO (14\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      as a 14\u2010day continuous infusion every 4\u2009weeks) at our Institute from January 2013 to April 2023. The analysis included patients\u2019 demographic and clinical characteristics, pathology details, treatment history, radiological response rates (RR), and toxicities per Common Terminology Criteria for Adverse Events (CTCAE) v5.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety eight patients were included in the analysis. Median age at diagnosis was 49\u2009years, 61% had previously received ifosfamide (IFO) and 83% anthracycline in earlier lines of treatment. Disease control rate (DCR) was 32%, with 9 PR and 22 stable disease (SD). Synovial sarcomas had the best (DCR) (60%). No statistically significant differences in DCR were seen according to sex, previous exposure to ifosfamide\u2010based CT, or ciIFO treatment line. mPFS was 3.0\u2009months; mOS was 11.2\u2009months. ciIFO was well tolerated, with an 11% discontinuation rate and no severe renal toxicity observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ciIFO showed activity across different lines of therapy, achieving a DCR of 32%, and appeared better tolerated than standard\u2010dose IFO regimens, even in a cohort of heavily pretreated patients (18% had an Eastern Cooperative Oncology Group performance status (ECOG PS) \u2265\u20092). Synovial and bone sarcoma patients derived the greatest benefit (6\u2010month PFS of 45% in both groups).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71614","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T01:14:08Z","timestamp":1771204448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Experience of Efficacy and Tolerability of Continuous Infusion Ifosfamide for Advanced Soft Tissue and Bone Sarcoma Patients: A Single Centre Retrospective Cohort"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3088-1255","authenticated-orcid":false,"given":"Ilaria","family":"Mascagni","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Laffi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Susanna","family":"Grimaudo","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-3373","authenticated-orcid":false,"given":"Ferdinando Carlo Maria","family":"Cananzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Sarcoma, Melanoma and Rare Tumor Surgery Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sam\u00e0","sequence":"additional","affiliation":[{"name":"Sarcoma, Melanoma and Rare Tumor Surgery Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-1318","authenticated-orcid":false,"given":"Salvatore Lorenzo","family":"Renne","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Department of Pathology IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"D\u2019Orazio","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierina","family":"Navarria","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Clerici","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Carnaghi","sequence":"additional","affiliation":[{"name":"Oncology Department Humanitas Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3906-6062","authenticated-orcid":false,"given":"Sara","family":"Farinatti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Stucchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialudovica","family":"Le Moli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giordano","sequence":"additional","affiliation":[{"name":"Biostatistic Unit, Humanitas Cancer Center IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Maki","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center  New York New York USA"},{"name":"School of Medical Sciences Weill\u2010Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"},{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia Francesca","family":"Bertuzzi","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Soft Tissue and Bone Tumors","author":"WHO Classification of Tumors Editorial Board","year":"2020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.1995"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509519"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70063-4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1276"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2022-0518"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008279426654"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13569-015-0029-8"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.7.1600"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2378"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-4-16"},{"key":"e_1_2_13_14_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0","author":"U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute","year":"2017"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.1.170"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199806000-00025"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1438"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.7717"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw430"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00908"},{"issue":"2","key":"e_1_2_13_21_1","first-page":"S174","article-title":"Single\u2010Agent Ifosfamide Studies in Sarcomas of Soft Tissue and Bone: The M.D. Anderson Experience","volume":"31","author":"Benjamin R. S.","year":"1993","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112389"},{"issue":"2","key":"e_1_2_13_23_1","first-page":"68","article-title":"Ifosfamide and Mesna: Response and Toxicity at Standard\u2010 and High\u2010Dose Schedules","volume":"17","author":"Antman K. H.","year":"1990","journal-title":"Seminars in Oncology"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.141"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113408"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12498-x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328795"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940515)73:10<2506::AID-CNCR2820731009>3.0.CO;2-S"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi082"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.022"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-11-1351"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00398-7"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140010-00004"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.6107"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.2.463"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-023-03221-6"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4734"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:27:03Z","timestamp":1786703223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cam4.71614"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71614","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71614"}}