{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:12Z","timestamp":1786706832533,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Evidence on structured exercise during systemic treatment for patients with locally advanced or metastatic pancreatic cancer is still limited, and detailed feasibility data in real\u2010world clinical settings remain scarce. This study aimed to assess the feasibility, safety, and preliminary efficacy of a 12\u2010week exercise intervention in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective single\u2010arm trial, 20 patients undergoing chemotherapy participated in a supervised exercise program comprising aerobic and resistance training, delivered twice weekly for 12\u2009weeks. Participants could choose between supervised gym\u2010based or home\u2010based sessions. Primary outcomes included recruitment, retention, attendance, adherence, tolerance, and safety. Secondary outcomes were changes in physical fitness and patient\u2010reported outcomes. Descriptive statistics and paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests or Wilcoxon signed\u2010rank tests were used for analyses. Exploratory subgroup analyses were conducted by tumor stage and exercise delivery mode.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The recruitment rate was 80%, with a 43% dropout rate primarily due to disease progression or treatment\u2010related toxicities. Median session attendance was 79%, and adherence to prescribed exercise volume reached 77%. Only three non\u2010serious adverse events were reported. Significant improvements were observed in grip strength (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), total weekly physical activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), and time spent in moderate\u2010intensity activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Emotional (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and social functioning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048) significantly improved, while appetite loss decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Subgroup analyses suggested greater benefits in patients with stage IV disease and those in the home\u2010based group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exercise during chemotherapy appears feasible and safe for patients with advanced\/metastatic pancreatic cancer, and it may help maintain physical fitness, enhance emotional and social well\u2010being, and alleviate appetite loss. However, different strategies are required to reduce the dropout rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71631","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:48:08Z","timestamp":1771314488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structured Exercise During Chemotherapy for Locally Advanced or Metastatic Pancreatic Cancer: A Single\u2010Arm, Feasibility Trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Anita","family":"Borsati","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Biomedical, Clinical and Experimental Sciences, Department of Medicine University of Verona  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Toniolo","sequence":"additional","affiliation":[{"name":"Department 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