{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:07:22Z","timestamp":1793902042926,"version":"4.8.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Primary poor graft function (PGF) is a common and serious complication after haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT). This study retrospectively evaluates the efficacy and safety of a novel combination therapy consisting of low\u2010dose decitabine, donor lymphocyte infusion (DLI), and eltrombopag for the treatment of primary PGF subsequent to haplo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this analysis of ten patients, decitabine was administered at a dose of 7\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day for three consecutive days, followed by DLI on the fifth day and eltrombopag, which was started at 50\u2009mg\/day and titrated up to 150\u2009mg. The primary endpoints of the study encompassed hematologic recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients (90%) achieved a complete response with normalized blood counts, while one patient (10%) showed a partial response with transfusion independence. Adverse events included manageable graft\u2010versus\u2010host disease (GVHD) in four patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that this triple therapy represents a promising approach for the management of primary PGF following haplo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71636","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:49:53Z","timestamp":1773632993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful Treatment of Primary Poor Graft Function After Haploidentical Hematopoietic Stem Cell Transplantation With Low\u2010Dose Decitabine Followed by Donor Lymphocyte Infusion and Eltrombopag"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiaojiao","family":"Yuan","sequence":"first","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Cao","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Ye","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyue","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhi","family":"Pei","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-3131","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Zhejiang China"},{"name":"Institute of Hematology, Ningbo University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2018.08.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.05.036"},{"issue":"7","key":"e_1_2_8_4_1","first-page":"935","article-title":"Boost of CD34+\u2010Selected Peripheral Blood Cells Without Further Conditioning in Patients With Poor Graft Function Following Allogeneic Stem Cell Transplantation","volume":"91","author":"Larocca A.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620720948743"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002790"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-04-0342"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"337","article-title":"The Effect of Decitabine on Megakaryocyte Maturation and Platelet Release","volume":"106","author":"Wang J.","year":"2011","journal-title":"Thrombosis and 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