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Three authors independently screened and evaluated the quality of the methodology. The main outcomes were the single proportion and the odds ratio (OR) of each constitution type across related health states of NPC, and the effect sizes were expressed as proportions or as ORs with 95% confidence intervals (CI). Sensitivity and subgroup analyses were performed to determine the sources of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data of 1174 patients from 11 different studies were included in the present study. Qi\u2010deficiency (QD), balanced, and Yang\u2010deficiency constitutions accounted for 25.5% (95% CI: 19.0\u201332.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), 16.1% (95% CI: 18.1\u201326.1), and 15.4% (95% CI: 9.5\u201321.4), respectively. The distribution across related health states of patients with NPC varied across different stages of the disease. QDC showed a significant association with both Epstein\u2013Barr virus infection and NPC diagnosed status in the included populations compared with that in healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>QDC is a major factor associated with NPC across different health statuses. However, the cross\u2010sectional nature of the available evidence highlights the need for more high\u2010quality prospective cohort studies to clarify the temporal relationship and causal role of specific constitutions in NPC development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71641","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:59:59Z","timestamp":1774587599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Nasopharyngeal Carcinoma and Chinese Medicine Constitution: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0940-2585","authenticated-orcid":false,"given":"Shun\u2010Qi","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences  Beijing China"},{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zi","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-4164","authenticated-orcid":false,"given":"Wen\u2010Le","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"},{"name":"College of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-6043","authenticated-orcid":false,"given":"Yu\u2010Yang","family":"Cai","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"},{"name":"College of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng\u2010Shuo","family":"Miao","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"},{"name":"College of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-6560","authenticated-orcid":false,"given":"Ming\u2010Hua","family":"Bai","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-8220","authenticated-orcid":false,"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33998"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190244"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"86","article-title":"Epidemiology, Incidence and Mortality of Nasopharynx Cancer in Southeast Asia: An Update Report","volume":"7","author":"Lao T. 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