{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:26:58Z","timestamp":1786706818362,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Papillary urothelial carcinoma (transitional cell carcinoma) is one of the most common malignant tumors of the urinary tract. Urothelial carcinomas are classified into muscle\u2010invasive and non\u2010muscle\u2010invasive types. Among the latter, papillary urothelial carcinoma is further categorized into low\u2010grade and high\u2010grade forms. The aggressiveness of bladder cancer depends on the stage and grade of the disease. The CacyBP\/SIP protein and MAP kinases play key roles in various cellular processes and signaling pathways that determine cell survival or death. This study aimed to assess the expression of CacyBP\/SIP, ERK1\/2, and p38 in low\u2010 and high\u2010grade papillary urothelial carcinoma using immunohistochemical and molecular analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Tissue samples were obtained from 20 patients with high\u2010grade urothelial carcinoma and 20 patients with low\u2010grade urothelial carcinoma. Adjacent non\u2010cancerous tissues served as comparative controls. Immunohistochemistry and qRT\u2010PCR were used to evaluate the expression of CacyBP\/SIP, ERK1\/2, and p38.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The strongest expression of the CacyBP\/SIP gene was observed in tumor tissues with high malignant potential, predominantly in the nuclear compartment. Similarly, p38 kinase expression was elevated, whereas ERK1\/2 expression was reduced in bladder tumor tissues compared to adjacent normal bladder tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that CacyBP\/SIP may play a critical role in urothelial carcinoma progression by modulating ERK1\/2 and p38 kinase activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71649","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T01:18:08Z","timestamp":1771204688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of\n                    <scp>CacyBP<\/scp>\n                    \/\n                    <scp>SIP<\/scp>\n                    ,\n                    <scp>ERK1<\/scp>\n                    \/2, and p38 Expression in Low\u2010 and High\u2010Grade Papillary Urothelial Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Natalia","family":"Domian","sequence":"first","affiliation":[{"name":"Department of Histology and Cytophysiology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"M\u0142ynarczyk","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-942X","authenticated-orcid":false,"given":"Irena","family":"Kasacka","sequence":"additional","affiliation":[{"name":"Department of Histology and Cytophysiology Medical University of Bia\u0142ystok  Bia\u0142ystok 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