{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:35:40Z","timestamp":1777890940538,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100216"],"award-info":[{"award-number":["82100216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Imeglimin (IME) is a novel oral anti\u2010diabetic agent with a similar chemical structure to metformin, which has shown broad\u2010spectrum anti\u2010tumor activity. However, the activity of imeglimin on tumor cells remains unclear. This study investigated the effects of IME on multiple myeloma (MM) cells and explored the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The effects of IME on MM cell proliferation were evaluated in\u00a0vitro using MM cell lines and in MM cell\u2010derived xenograft (CDX) models. Seahorse metabolic analyses and RNA\u2010Seq were performed in IME\u2010treated and control MM cell lines. Single\u2010cell transcriptomic data were further analyzed to assess the role of IL\u201016 in the bone marrow microenvironment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IME inhibited MM cell proliferation and tumor growth in MM cell\u2010derived xenograft (CDX) models by inducing G1\/G0 cell cycle arrest. IME suppressed oxidative phosphorylation and promoted glycolysis. IL\u201016 mRNA expression was downregulated, and multiple cytokine\u2013cytokine receptor interaction pathways were altered following IME treatment. The anti\u2010MM effect of IME was partly mediated by increased lactate production and decreased IL\u201016 expression. Single\u2010cell transcriptomic data further demonstrated that IL\u201016 plays an important role in the bone marrow microenvironment of MM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that IME may represent a novel approach for targeting IL\u201016 and energy metabolism in the treatment of MM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71651","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:44:39Z","timestamp":1772963079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imeglimin Exerts Anti\u2010Tumor Activity in Multiple Myeloma Through Affecting Energy Metabolism and Downregulating\n                    <scp>IL<\/scp>\n                    \u201016 Expression"],"prefix":"10.1002","volume":"15","author":[{"given":"Jifeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hematology Huadong Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai 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