{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:43:39Z","timestamp":1788921819148,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3N1331"],"award-info":[{"award-number":["CMRPG3N1331"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world evidence regarding the use of dacomitinib as a first\u2010line therapy for advanced non\u2010small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations remains limited. This multicenter, retrospective cohort study aimed to evaluate the clinical outcomes of dacomitinib as a first\u2010line treatment in patients with untreated advanced EGFR\u2010mutant NSCLC without brain metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included 161 patients with stage IIIB\/IV EGFR\u2010mutant NSCLC without brain metastasis at baseline who received first\u2010line dacomitinib between October 2020 and August 2023 at four Taiwanese cancer centers. The primary outcomes included the objective response rate (ORR), progression\u2010free survival (PFS), overall survival (OS), predictive risk factors for PFS, and adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ORR was 64.0%, and the disease control rate (DCR) reached 91.3%. The median PFS was 20.93\u2009months (95% CI: 17.55\u201324.32), and the median OS was 41.27\u2009months (95% CI: 31.71\u201350.82). Multivariate analysis revealed that an Eastern Cooperative Oncology Group (ECOG) performance status (PS) \u2265\u20092, bone metastasis, and liver metastasis were independent predictors of shorter PFS. Among patients who experienced disease progression and underwent rebiopsy, the secondary T790M mutation rate was 50.6%. Most treatment\u2010related AEs were grade 1\u20132 and manageable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dacomitinib demonstrated favorable efficacy and tolerability as a first\u2010line therapy in advanced NSCLC patients with common EGFR mutations (exon 19 deletion or L858R). A baseline ECOG PS \u2265\u20092 and the presence of bone or liver metastases were significantly associated with worse PFS, suggesting a need for additional therapeutic strategies in these subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71659","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:58:20Z","timestamp":1772963900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dacomitinib as a First\u2010Line Therapy for Advanced\n                    <scp>EGFR<\/scp>\n                    \u2010Mutated Non\u2010Small Cell Lung Cancer Without Brain Metastases: A Multicenter Retrospective Observational Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Ping\u2010Chih","family":"Hsu","sequence":"first","affiliation":[{"name":"Division of Thoracic Medicine, Department of Internal Medicine Chang Gung Memorial Hospital at Linkou  Taoyuan City Taiwan"},{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"How\u2010Wen","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Thoracic Medicine, Department of Internal Medicine Chang Gung Memorial Hospital at Linkou  Taoyuan City Taiwan"},{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Chung","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Thoracic Medicine, Department of Internal Medicine Chang Gung Memorial Hospital at Linkou  Taoyuan City Taiwan"},{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine New Taipei Municipal TuCheng Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Shu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Department of Thoracic Medicine New Taipei Municipal TuCheng Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Division of Thoracic Oncology, Department of Respiratory and Critical Care Medicine Chang Gung Memorial Hospital, Chiayi Branch  Chiayi County Taiwan"},{"name":"Department of Respiratory Care Chang Gung University of Science and Technology, Chiayi Campus  Chiayi County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott Chih\u2010Hsi","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Thoracic Medicine, Department of Internal Medicine Chang Gung Memorial Hospital at Linkou  Taoyuan City Taiwan"},{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Shiuan","family":"Ju","sequence":"additional","affiliation":[{"name":"Division of Thoracic Medicine, Department of Internal Medicine Chang Gung Memorial Hospital at Linkou  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Chou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Division of Pulmonary &amp; 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