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We aimed to assign HIV status to cancers diagnosed in public laboratories recorded in the National Cancer Registry (NCR) in South Africa, guided by HIV counselling and testing guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used natural language processing to extract HIV\u2010related information from free\u2010text reports and probabilistic record linkage to match cancers diagnosed between 2004 and 2021 to HIV\u2010related tests from the National Health Laboratory Service Corporate Data Warehouse. We assigned HIV status based on the results of the HIV\u2010related tests and their timing relative to cancer diagnosis. We used descriptive statistics and logistic regression to examine HIV status documentation patterns and HIV prevalence in cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 496,517 cancers reported to the NCR, 41% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009203,937) had a documented HIV status. Documentation increased from 29% in 2004\u20132009 to 52% in 2016\u20132021. The odds of having a documented HIV status were 20% higher in females than in males and 16%\u201328% lower in other population groups compared with Black Africans. Patients with infection\u2010related cancers had almost threefold higher odds of having a documented HIV status than patients with infection\u2010unrelated cancers. Among cancer patients with documented HIV status, HIV prevalence was 75% for infection\u2010related and 32% for infection\u2010unrelated cancers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIV status documentation among people with cancer has improved over time, but it is still suboptimal. Clinicians and pathologists in HIV endemic areas need to improve HIV ascertainment at cancer diagnosis and reporting to cancer registries to inform patient care and guide cancer control efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71661","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:49:57Z","timestamp":1772963397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integration of\n                    <scp>HIV<\/scp>\n                    Status in Cancer Surveillance in South Africa: A Call for Action"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-8280","authenticated-orcid":false,"given":"Carole","family":"Metekoua","sequence":"first","affiliation":[{"name":"National Cancer Registry, National Health Laboratory Service  Johannesburg South Africa"},{"name":"Graduate School for Health Sciences University 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