{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:34:26Z","timestamp":1777890866738,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      As the data on\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      \u2010associated breast and ovarian cancer prevalence after prophylactic surgery has not been exhaustively investigated yet, we aimed to evaluate the cancer prevalence in a single center cohort of\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>BRCA2<\/jats:italic>\n                      carriers after conducting prophylactic mastectomy, as well as prophylactic bilateral salpingo\u2010oophorectomy (PBSO) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 875 women that were tested positive for a germline variant in the\n                      <jats:italic>BRCA1\/BRCA2<\/jats:italic>\n                      gene (gPV) between 2002 and 2022 at the Center of Hereditary Breast and Ovarian Cancer of the Technical University Munich Germany. Mean follow up was 7.2\u2009years (range 0\u201344\u2009years; 95% CI: 6.70 to 7.70). We differentiated breast and\/or ovarian cancer diseased (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009643) and non\u2010diseased\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      carriers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009232).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis confirmed the effectiveness of prophylactic surgeries in genetically predisposed women with a gPV in the\n                      <jats:italic>BRCA1<\/jats:italic>\n                      \/2 gene. We observed no breast cancer after prophylactic bilateral mastectomy, 2 contralateral breast cancer diseases after contralateral prophylactic mastectomy and 1 extraovarian serous adenocarcinoma after PBSO. Within the entire study collective, a total of 293 have undergone PBSO, with 6 women having an incidental finding of ovarian cancer and STIC respectively (=2.0%; 1.7%\n                      <jats:italic>gBRCA1<\/jats:italic>\n                      and 0.3%\n                      <jats:italic>gBRCA2<\/jats:italic>\n                      ). Our data suggests that, particularly regarding ipsilateral secondary cancer (ISC), higher oncological safety can be achieved through mastectomy rather than breast\u2010conserving surgery (BCS). In the group of patients who had a second breast cancer and were treated with BCS during their first cancer, 18.3% showed an ISC. Within the patients who were first treated with a mastectomy, only 4.3% showed an ISC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Prophylactic surgeries demonstrate high oncological effectiveness in gPV\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      carriers. In particular, mastectomy may provide greater protection against ISC compared with BCS. Further studies will have to be conducted to compare ipsilateral cancer prevalence after breast\u2010sparing surgery and mastectomy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71691","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:35:34Z","timestamp":1773056134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo\u2010Oophorectomy in\n                    <scp>BRCA1<\/scp>\n                    \/2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4688-4704","authenticated-orcid":false,"given":"Sara","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar Technical University Munich (TUM)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Yahiaoui\u2010Doktor","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Fallenberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Klinikum Rechts der Isar Technical University of Munich (TUM)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-2657","authenticated-orcid":false,"given":"Marion","family":"Kiechle","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar Technical University Munich (TUM)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar Technical University Munich (TUM)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Robert\u2010Koch\u2010Institut \u201cKrebs in Deutschland f\u00fcr 2019\/2020 Brustdr\u00fcse \u201d2023."},{"key":"e_1_2_11_3_1","first-page":"401","volume-title":"Manual Mammakarzinom, Empfehlungen zur Diagnostik, Therapie, Nachsorge und Begleitung","author":"Ettl 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