{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:58:49Z","timestamp":1779289129359,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["201640158"],"award-info":[{"award-number":["201640158"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the long\u2010term survival outcomes of concurrent chemoradiation (CCRT) for high\u2010risk salivary gland carcinomas (SGCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Postoperative patients with high\u2010risk SGCs, other than adenoid cystic carcinoma (ACC), with T3\u20104\/N1\u20103M0 disease were enrolled. This study included a cohort of 55 patients who received CCRT, derived from a prospective phase II trial, and a retrospective cohort of 61 patients treated with RT alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up for survivors was 54.1\u2009months. In the subgroup analysis, patients without ENE treated with CCRT showed significantly better 5\u2010year OS (83.4% vs. 69.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), with a numerically higher 5\u2010year DFS (57.3% vs. 41.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.062). In the subgroup of patients with N0\u20101 disease, those treated with CCRT showed a numerically higher 5\u2010year DFS (69.1% vs. 44.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.073) and OS (90.7% vs. 76.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.057). On multivariate analyses, CCRT significantly predicted superior DFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) and OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) for patients without ENE and superior DFS (p\u2009=\u20090.027) for patients with N0\u20101 disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For postoperative high\u2010risk non\u2010ACC SGCs, CCRT was associated with improved long\u2010term survival outcomes in patients without ENE or with N0\u20101 disease, which need further evaluation in randomized trials. However, for patients with ENE or N2\u20103 disease, they may need alternative treatment strategies to enhance their prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The prospective cohort analyzed in this study originated from the non\u2010ACC group enrolled in a phase 2 clinical trial (NCT02776163)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71722","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:13:00Z","timestamp":1774433580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Survival Outcomes of Concurrent Chemoradiotherapy for Postoperative High\u2010Risk Salivary Gland 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