{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:25Z","timestamp":1790007325310,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Head and neck cancer presents a significant challenge for patients. Beyond the direct impact of the disease, chemotherapy and radiotherapy, while essential for cancer control, can further compromise patients' quality of life (QoL) and emotional well\u2010being, while also introducing additional complications. These treatments may exacerbate existing cancer\u2010related symptoms and contribute to malnutrition. This review aimed to identify and evaluate physical prehabilitation interventions implemented before or during radiotherapy\/chemotherapy treatments to determine their impact on the QoL of patients with head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This scoping review was structured according to the framework proposed by the Joanna Briggs Institute (JBI) and reported following the Preferred Reporting Items for Scoping Reviews (PRISMA\u2010ScR) guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies were included, encompassing a total sample of 819 subjects (397 in experimental groups). The interventions identified included exercises and stretching to prevent mobility issues and trismus, home\u2010based training programs with periodic supervision, comprehensive programs with supervised physiotherapy sessions, jaw mobility exercises, dysphagia therapy, oral exercises, and preventive rehabilitation. A positive association was found between prehabilitation interventions and improved QoL in patients. Customizing interventions based on patient characteristics and treatment modalities was shown to enhance the effectiveness of these programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prehabilitation interventions represent a holistic and functional approach to improving patient outcomes and QoL. Further research is needed to refine these approaches and optimize the overall QoL of head and neck cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71743","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:42:13Z","timestamp":1774608133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Quality of Life in Head and Neck Cancer: A Scoping Review on the Role of Physical Prehabilitation"],"prefix":"10.1002","volume":"15","author":[{"given":"Alice Maria","family":"Santagostino","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-2790","authenticated-orcid":false,"given":"Mauro","family":"Parozzi","sequence":"additional","affiliation":[{"name":"School of Nursing, \u201cSan Paolo\u201d Campus, Asst Santi Paolo e Carlo University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-6906","authenticated-orcid":false,"given":"Giovanni","family":"Cangelosi","sequence":"additional","affiliation":[{"name":"Units of Diabetology ASUR Marche  Marche Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3884-4823","authenticated-orcid":false,"given":"Sara Morales","family":"Palomares","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences (DFSSN) University of Calabria  Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-4391","authenticated-orcid":false,"given":"Stefano","family":"Mancin","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia De","family":"Pasquale","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Petrelli","sequence":"additional","affiliation":[{"name":"School of Pharmacy Polo Medicina Sperimentale e Sanit\u00e0 Pubblica \u201cStefania Scuri\u201d  Marche Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sguanci","sequence":"additional","affiliation":[{"name":"A.O. Polyclinic San Martino Hospital  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3870-1238","authenticated-orcid":false,"given":"Beatrice","family":"Mazzoleni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21343"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359\u2010023\u201001264\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2023.06.047"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070\u2010019\u201001620\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S103203"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17196938"},{"issue":"8","key":"e_1_2_10_8_1","first-page":"1218","article-title":"The Most Common Side Effects Experienced by Patients Were Receiving First Cycle of Chemotherapy","volume":"47","author":"Altun \u0130.","year":"2018","journal-title":"Iran J Public Health"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.06.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2019.01.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2024.102569"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2023.10.033"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare8020102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040574"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5603\/NJO.a2022.0036"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12254\u2010021\u201000686\u20105"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.598425"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463\u2010020\u201000486\u20107"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2023.2274230"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2022.08.031"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13549"},{"key":"e_1_2_10_22_1","unstructured":"University of Calgary \u201cMultiphasic Prehabilitation in Patients Undergoing Surgery for Head and Neck Cancer [Internet] \u201dclinicaltrials.gov; 2022 Feb [cited 2023 Jan 1]. 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